B6.129-Grin1tm1Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09220 |
| International strain name | B6.129-Grin1tm1Rsp/Kctt |
| Alternative name | Grin1-2lox/Rsp (lab name NR1-2lox) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Grin1tm1Rsp, |
| Gene/Transgene symbol | Grin1 |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | Mice with (loxP5171) (Lee & Saito, 1998) flanking the gene for the principal NMDA receptor subunit GluN1 (Grin1 gene; exons 11–18) were generated by gene targeting in embryonic stem cells. No selection marker is present and two loxP sites are flanking part of the Grin1 gene. |
| Phenotypic information | Homozygous:No PhenotypeHeterozygous:No Phenotype |
| Breeding history | Embryos from 2013. Line was generated 2000 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous C57BL/6 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Bilateral generalized polymicrogyria / Orphanet_208447
Literature references
- Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus.;Niewoehner B, Single F N, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg P H, Rawlins J N P, Sprengel R, Bannerman D M, ;2007;The European journal of neuroscience;25;837-46; 17313573
- Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.;Bannerman David M, Bus Thorsten, Taylor Amy, Sanderson David J, Schwarz Inna, Jensen Vidar, Hvalby Øivind, Rawlins J Nicholas P, Seeburg Peter H, Sprengel Rolf, ;2012;Nature neuroscience;15;1153-9; 22797694
- Cre-Activation in ErbB4-Positive Neurons of Floxed Grin1/NMDA Receptor Mice Is Not Associated With Major Behavioral Impairment.;Mallien Anne S, Pfeiffer Natascha, Vogt Miriam A, Chourbaji Sabine, Sprengel Rolf, Gass Peter, Inta Dragos, ;2021;Frontiers in psychiatry;12;750106; 34899420