MGI phenotypes (allele matching)
B6.129-Grin1tm2Phs/Kctt
| Status | Available to order |
| EMMA ID | EM:09287 |
| International strain name | B6.129-Grin1tm2Phs/Kctt |
| Alternative name | Grin1Rneo/+ (Lab name B6.NR1M2Rneo) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Grin1tm2Phs, |
| Gene/Transgene symbol | Grin1 |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | Cre inducible activation of the silenced single amino acid mutation of the mutation N-methy-D-aspartate-receptor gene (NMDAR). |
| Phenotypic information | Homozygous:LethalHeterozygous:No obvious phenotype |
| Breeding history | Embryos from matings of heterozygote Grin1Rneo/+ and C57BL/6N females were harvested and 30 embryos were cryoconserved in 2011. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6N, wild-type C57BL/6N |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Bilateral generalized polymicrogyria / Orphanet_208447
- Early infantile epileptic encephalopathy / Orphanet_1934
Literature references
- Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R).;Single F N, Rozov A, Burnashev N, Zimmermann F, Hanley D F, Forrest D, Curran T, Jensen V, Hvalby O, Sprengel R, Seeburg P H, ;2000;The Journal of neuroscience : the official journal of the Society for Neuroscience;20;2558-66; 10729336