MGI phenotypes (allele matching)
STOCK Eif2ak4tm1.2Dron/Cnbc
| Status | Available to order |
| EMMA ID | EM:09406 |
| Citation information | RRID:IMSR_EM:09406 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Eif2ak4tm1.2Dron/Cnbc |
| Alternative name | Eif2ak4_tm1.2Dron_GCN2deficient |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Eif2ak4tm1.2Dron |
| Gene/Transgene symbol | Eif2ak4 |
Information from provider
| Provider | Juanjo Berlanga |
| Provider affiliation | Genome Dynamics and Function, Centro de Biología Molecular Severo Ochoa (CSIC-UAM) |
| Additional owner | Dr. David Ron, University of Cambridge, Cambridge, UK |
| Genetic information | Eif2ak4_GCN2-deficient gene (GCN2 allele constitutively missing exon XII (GCN2). Exon XII encodes a region of GCN2 that binds ATP, and its deletion eliminates kinase activity. |
| Phenotypic information | Homozygous:GCN2 homozygous mutant mice exhibit a less aversive response towards imbalanced diet, therefore eIF2 kinase GCN2 has an important role in mediating aversion toward foods with an imbalanced amino acid composition. GCN2-induced eIF2 phosphorylation may promote the aversive response through its effects on translation and transcription in cells of the Anterior Piriform Cortex (APC), in other brain regions, and in other peripheral organs.Heterozygous:GCN2 heterozygous mutant mice, exhibit a wild-type aversive response toward foods with an imbalanced amino acid composition. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous 129/Sv (synonym: 129Sv) males, homozygous 129/Sv (synonym: 129Sv) females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Heritable pulmonary arterial hypertension / Orphanet_275777
- Pulmonary venoocclusive disease / Orphanet_31837
- Pulmonary capillary hemangiomatosis / Orphanet_199241
MGI phenotypes (gene matching)
- abnormal eating behavior / MGI
- abnormal food preference / MGI
- abnormal contextual conditioning behavior / MGI
- postnatal growth retardation / MGI
- increased litter size / MGI
- decreased litter size / MGI
- abnormal long term potentiation / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to viral infection / MGI
- abnormal macrophage physiology / MGI
- increased growth rate / MGI
- abnormal cytokine secretion / MGI
- decreased liver weight / MGI
- maternal effect / MGI
- decreased skeletal muscle mass / MGI
- abnormal circulating amino acid level / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal spatial reference memory / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to weight loss / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
Literature references
- The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.;Maurin Anne-Catherine, Jousse Céline, Averous Julien, Parry Laurent, Bruhat Alain, Cherasse Yoan, Zeng Huiqing, Zhang Yuhong, Harding Heather P, Ron David, Fafournoux Pierre, ;2005;Cell metabolism;1;273-7; 16054071
- Regulated translation initiation controls stress-induced gene expression in mammalian cells.;Harding H P, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D, ;2000;Molecular cell;6;1099-108; 11106749