B6;129-Rev3ltm1Crey/Cnbc
| Status | Available to order |
| EMMA ID | EM:10791 |
| International strain name | B6;129-Rev3ltm1Crey/Cnbc |
| Alternative name | B6-129-Rev3L(catlytic mutant) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Rev3ltm1Crey, |
| Gene/Transgene symbol | Rev3l |
Information from provider
| Provider | Claude-Agnes Reynaud |
| Provider affiliation | INSERM U1151/CNRS UMR 8253, Institut Necker-Enfants Malades |
| Genetic information | Knock-in mutations of the catalytic site of Rev3l DNA polymerase. |
| Phenotypic information | Homozygous:No obvious phenotype.Heterozygous:No obvious phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6;129 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Moebius syndrome / Orphanet_570
Literature references
- A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.;Fritzen Rémi, Delbos Frédéric, De Smet Annie, Palancade Benoît, Canman Christine E, Aoufouchi Said, Weill Jean-Claude, Reynaud Claude-Agnès, Storck Sébastien, ;2016;DNA repair;46;37-46; 27481099