CBA.B6-Tnfrsf1atm1Blt Tg(CD2-TNF/HBB)211Gkl/Flmg

Status

Available to order

EMMA IDEM:11021
International strain nameCBA.B6-Tnfrsf1atm1Blt Tg(CD2-TNF/HBB)211Gkl/Flmg
Alternative nameCBA.B6-Tnfrsf1a Tg(CD2-TNF/HBB)211Gkl/Flmg
Strain typeTransgenic Strains
Allele/Transgene symbolTg(CD2-TNF/HBB)211Gkl
Gene/Transgene symbolTg(CD2-TNF/HBB)211Gkl

Information from provider

ProviderGeorge Kollias
Provider affiliationB.S.R.C.
Genetic informationThe transgene comprises the T cell specific human CD2 gene locus control region (LCR) linked to the entire coding region of the human TNF gene with polyadenylation signal and flanking sequences replaced by those of the human hemoglobin beta (HBB) gene. This modification does not interfere with correct translation.
Phenotypic informationHomozygous:
embryonic lethality

Heterozygous:
Lethal wasting syndrome and lymphoid abnormalities. 80-100% mortality occurs within 71-127 days. Affected mice become hunched and unhealthy in appearance typically between 2 and 4 weeks of age. They demonstrate poor growth rates and subsequently severe weight loss. Line is maintained in TNFR1+/- background so that pathology is attenuated.
References
  • Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.;Probert L, Keffer J, Corbella P, Cazlaris H, Patsavoudi E, Stephens S, Kaslaris E, Kioussis D, Kollias G, ;1993;Journal of immunology (Baltimore, Md. : 1950);151;1894-906; 8345187
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivingheterozygous CBA x C57BL/6, wild-type (CBA x C57BL/6)F1
Stage of embryosMorula

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
MGI phenotypes (allele matching)
  • abnormal response/metabolism to endogenous compounds / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal sleep pattern / MGI
  • impaired central nervous system regeneration / MGI
  • increased sensitivity to induced cell death / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • impaired humoral immune response / MGI
  • decreased susceptibility to bacterial infection / MGI
  • decreased circulating alanine transaminase level / MGI
  • abnormal Peyer's patch morphology / MGI
  • abnormal immune system physiology / MGI
  • abnormal lymph node B cell domain morphology / MGI
  • abnormal Peyer's patch follicle morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • decreased Peyer's patch number / MGI
  • absent follicular dendritic cells / MGI
  • decreased IgG1 level / MGI
  • decreased interleukin-6 secretion / MGI

Literature references

  • Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.;Probert L, Keffer J, Corbella P, Cazlaris H, Patsavoudi E, Stephens S, Kaslaris E, Kioussis D, Kollias G, ;1993;Journal of immunology (Baltimore, Md. : 1950);151;1894-906; 8345187

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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