STOCK Tnfrsf1atm1Blt Tg(Tnf)6074Gkl/Flmg

Status

Available to order

EMMA IDEM:11023
International strain nameSTOCK Tnfrsf1atm1Blt Tg(Tnf)6074Gkl/Flmg
Alternative nameTg6074 [CBA.B6-Tnfrsf1a Tg(Tnf)6074Gkl/Flmg]
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTnfrsf1atm1Blt,
Gene/Transgene symbolTnfrsf1a

Information from provider

ProviderGeorge Kollias
Provider affiliationBSRC Fleming
Genetic informationThe transgene comprises the promoter and the entire coding region of the murine Tnf gene. Polyadenylation signal and flanking sequence were replaced by those of the human hemoglobin beta (HBB) gene. Line 6074 carries more than 100 copies of the transgene. RNA analysis from Tg6074 tissues, demonstrated that the transgene is expressed specifically in the CNS.
Phenotypic informationHomozygous:
Phenotype exhibited is more severe; specific reproduction scheme suggested under husbandry to keep mice in heterozygosity.

Heterozygous:
Transgenic mice develop severe neurological disturbances with 100% phenotypic penetrance and die prematurely, within about 8 months.
References
  • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.;Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G, ;1995;Proceedings of the National Academy of Sciences of the United States of America;92;11294-8; 7479982
Homozygous fertileno
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivingheterozygous C57BL/6, wild-type C57BL/6
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
MGI phenotypes (allele matching)
  • abnormal response/metabolism to endogenous compounds / MGI
  • decreased circulating interleukin-6 level / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal sleep pattern / MGI
  • impaired central nervous system regeneration / MGI
  • increased sensitivity to induced cell death / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • impaired humoral immune response / MGI
  • decreased susceptibility to bacterial infection / MGI
  • decreased circulating alanine transaminase level / MGI
  • abnormal Peyer's patch morphology / MGI
  • abnormal immune system physiology / MGI
  • abnormal lymph node B cell domain morphology / MGI
  • abnormal Peyer's patch follicle morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased susceptibility to type I hypersensitivity reaction / MGI
  • decreased Peyer's patch number / MGI
  • absent follicular dendritic cells / MGI
  • decreased IgG1 level / MGI
  • decreased interleukin-6 secretion / MGI

Literature references

  • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.;Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G, ;1995;Proceedings of the National Academy of Sciences of the United States of America;92;11294-8; 7479982

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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