- abnormal response/metabolism to endogenous compounds / MGI
- decreased circulating interleukin-6 level / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal sleep pattern / MGI
- impaired central nervous system regeneration / MGI
- increased sensitivity to induced cell death / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- impaired humoral immune response / MGI
- decreased susceptibility to bacterial infection / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal immune system physiology / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal Peyer's patch follicle morphology / MGI
- increased susceptibility to bacterial infection / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- increased susceptibility to parasitic infection / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased Peyer's patch number / MGI
- absent follicular dendritic cells / MGI
- decreased IgG1 level / MGI
- decreased interleukin-6 secretion / MGI
STOCK Tnfrsf1atm1Blt Tg(Tnf)6074Gkl/Flmg
Status | Available to order |
EMMA ID | EM:11023 |
International strain name | STOCK Tnfrsf1atm1Blt Tg(Tnf)6074Gkl/Flmg |
Alternative name | Tg6074 [CBA.B6-Tnfrsf1a |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tnfrsf1atm1Blt, |
Gene/Transgene symbol | Tnfrsf1a |
Information from provider
Provider | George Kollias |
Provider affiliation | BSRC Fleming |
Genetic information | The transgene comprises the promoter and the entire coding region of the murine Tnf gene. Polyadenylation signal and flanking sequence were replaced by those of the human hemoglobin beta (HBB) gene. Line 6074 carries more than 100 copies of the transgene. RNA analysis from Tg6074 tissues, demonstrated that the transgene is expressed specifically in the CNS. |
Phenotypic information | Homozygous:Phenotype exhibited is more severe; specific reproduction scheme suggested under husbandry to keep mice in heterozygosity.Heterozygous:Transgenic mice develop severe neurological disturbances with 100% phenotypic penetrance and die prematurely, within about 8 months. |
References |
|
Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | heterozygous C57BL/6, wild-type C57BL/6 |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
MGI phenotypes (allele matching)
Literature references
- Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.;Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G, ;1995;Proceedings of the National Academy of Sciences of the United States of America;92;11294-8; 7479982
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).