C57BL/6-Setdb2tm1a(KOMP)Wtsi/Biat

Status

Available to order

EMMA IDEM:11046
International strain nameC57BL/6-Setdb2tm1a(KOMP)Wtsi/Biat
Alternative nameSetdb2
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSetdb2tm1a(KOMP)Wtsi
Gene/Transgene symbolSetdb2

Information from provider

ProviderDavid Symer
Provider affiliationDept. of Lymphoma & Myeloma, Univ. Texas MD Anderson Cancer Center
Genetic informationA gene-trap construct together with loxP sites were introduced up- and downstream of exon 6 of Setdb2. The knockout first allele is initially a non-expressive form, but can be converted to a conditional allele via flp recombinase-mediated recombination.
Phenotypic informationHomozygous:
altered immune response

Heterozygous:
not performed
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous C57BL/6

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal gait / IMPC
  • increased startle reflex / IMPC
  • thrombocytopenia / IMPC
  • increased grip strength / IMPC
IMPC phenotypes (gene matching)
  • increased grip strength / IMPC
  • thrombocytopenia / IMPC
  • abnormal gait / IMPC
  • increased startle reflex / IMPC
MGI phenotypes (gene matching)
  • increased neutrophil cell number / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal response to infection / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).