B6;D2-Tg(Cd4-cre)1Cwi/CwiCnrm

Status	Available to order
EMMA ID	EM:01139
International strain name	B6;D2-Tg(Cd4-cre)1Cwi/CwiCnrm
Alternative name	CD4-Cre
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Cd4-cre)1Cwi,
Gene/Transgene symbol	Tg(Cd4-cre)1Cwi

Information from provider

Provider	Chris Wilson
Provider affiliation	Department of Immunology, University of Washington, Dept. Immunology
Genetic information	CD4-cre mice specifically express the P1 bacteriophage cre recombinase in T-cells.
Phenotypic information	CD4-cre mice have been shown to efficiently delete loxP-flanked genes in the T-cell lineage.
Breeding history	(C57BL/6 x DBA/2)F2 background; backcrossed to C57BL/6 (2-3 generations).
References	A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.;Lee P P, Fitzpatrick D R, Beard C, Jessup H K, Lehar S, Makar K W, Pérez-Melgosa M, Sweetser M T, Schlissel M S, Nguyen S, Cherry S R, Tsai J H, Tucker S M, Weaver W M, Kelso A, Jaenisch R, Wilson C B, ;2001;Immunity;15;763-74; 11728338

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.;Lee P P, Fitzpatrick D R, Beard C, Jessup H K, Lehar S, Makar K W, Pérez-Melgosa M, Sweetser M T, Schlissel M S, Nguyen S, Cherry S R, Tsai J H, Tucker S M, Weaver W M, Kelso A, Jaenisch R, Wilson C B, ;2001;Immunity;15;763-74; 11728338

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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