DW-Leprdb-Pas/Orl

Status

Available to order

EMMA IDEM:01167
International strain nameDW-Leprdb-Pas/Orl
Alternative namediabete-Pasteur
Strain typeSpontaneous
Allele/Transgene symbolLeprdb-Pas,
Gene/Transgene symbolLepr

Information from provider

ProviderJean-Louis Guénet
Provider affiliationInstitut Pasteur
Genetic informationSouthern analysis indicates that the mutation in the Pas allele is a partial duplication of the coding sequence for the putative extracellular domain of the Lepr protein.
Phenotypic informationObesity.
Breeding historyBred by crossing heterozygous mice.
References
  • A mutation in the DW inbred line producting an obese phenotype;Guenet JL;1982;Mouse News Lett.;67;30; 3882910
  • Description of a new model of genetic obesity: the dbPas mouse.;Aubert R, Herzog J, Camus M C, Guenet J L, Lemonnier D, ;1985;The Journal of nutrition;115;327-33;

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased brown adipose tissue amount / MGI
  • short tail / MGI
  • enlarged liver / MGI
  • enlarged spleen / MGI
  • obese / MGI
  • polyphagia / MGI
  • hyperglycemia / MGI
  • male infertility / MGI
  • female infertility / MGI
  • increased circulating insulin level / MGI
  • short femur / MGI
  • decreased muscle weight / MGI
  • increased circulating cholesterol level / MGI
  • increased total body fat amount / MGI

Literature references

  • A mutation in the DW inbred line producting an obese phenotype;Guenet JL;1982;Mouse News Lett.;67;30; 3882910
  • Description of a new model of genetic obesity: the dbPas mouse.;Aubert R, Herzog J, Camus M C, Guenet J L, Lemonnier D, ;1985;The Journal of nutrition;115;327-33;

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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