- increased brown adipose tissue amount / MGI
- short tail / MGI
- enlarged liver / MGI
- enlarged spleen / MGI
- obese / MGI
- polyphagia / MGI
- hyperglycemia / MGI
- male infertility / MGI
- female infertility / MGI
- increased circulating insulin level / MGI
- short femur / MGI
- decreased muscle weight / MGI
- increased circulating cholesterol level / MGI
- increased total body fat amount / MGI
DW-Leprdb-Pas/Orl
Status | Available to order |
EMMA ID | EM:01167 |
International strain name | DW-Leprdb-Pas/Orl |
Alternative name | diabete-Pasteur |
Strain type | Spontaneous |
Allele/Transgene symbol | Leprdb-Pas, |
Gene/Transgene symbol | Lepr |
Information from provider
Provider | Jean-Louis Guénet |
Provider affiliation | Institut Pasteur |
Genetic information | Southern analysis indicates that the mutation in the Pas allele is a partial duplication of the coding sequence for the putative extracellular domain of the Lepr protein. |
Phenotypic information | Obesity. |
Breeding history | Bred by crossing heterozygous mice. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Obesity due to leptin receptor gene deficiency / Orphanet_179494
MGI phenotypes (allele matching)
Literature references
- A mutation in the DW inbred line producting an obese phenotype;Guenet JL;1982;Mouse News Lett.;67;30; 3882910
- Description of a new model of genetic obesity: the dbPas mouse.;Aubert R, Herzog J, Camus M C, Guenet J L, Lemonnier D, ;1985;The Journal of nutrition;115;327-33;
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