B6(Cg)-Tg(Th-rtTA)4Ekra/EkraH
| Status | Available to order |
| EMMA ID | EM:11951 |
| International strain name | B6(Cg)-Tg(Th-rtTA)4Ekra/EkraH |
| Alternative name | C57BL/6J-Tg(TH-rtTA3G)4EKra |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Unknown at present |
| Gene/Transgene symbol | mTH-rtTA3G |
Information from provider
| Provider | Edgar Kramer |
| Provider affiliation | Biomedical Research, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth |
| Genetic information | rtTA3G under the control of the mouse Th promoter (8.9kbp). |
| Phenotypic information | Homozygous:Not generated.Heterozygous:mTH-rtTA ON#3205 can be used to induce rtTA expression in catecholaminergic neurons expressing tyrosine hydroxylase; rtTA can induce gene expression in the presence of tetracycline/doxycycline (Tillack et al., 2015). No obvious phenotype has been observed in the heterozygous mice. |
| Breeding history | Intercrosses with C57BL/6 x BALB/c F2-Tg(tetO-cre)LC1Bjd mouse line. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- An Efficient and Versatile System for Visualization and Genetic Modification of Dopaminergic Neurons in Transgenic Mice.;Tillack Karsten, Aboutalebi Helia, Kramer Edgar R, ;2015;PloS one;10;e0136203; 26291828