B6.129S2-Evx2/Hoxd13tm4(cre)Ddu/Orl
Status | Available to order |
EMMA ID | EM:01216 |
International strain name | B6.129S2-Evx2/Hoxd13tm4(cre)Ddu/Orl |
Alternative name | B6.129S2 TgN13(d11Cre) |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Evx2/Hoxd13tm4(cre)Ddu, |
Gene/Transgene symbol | Hoxd13 |
Information from provider
Provider | Duboule Denis |
Provider affiliation | Laboratoire Moléculaire et Morphogenèse |
Genetic information | Insertion, by homologous recombination, of the Hoxd11Cre transgene between Evx2 and Hoxd13. In this transgene the sequence of cre recombinase with a polyadenylation signal is introduced within the first exon of inserted Hoxd11 gene; the partial gene replacement leads to the synthesis of the cre recombinase without any residues from Hoxd11. |
Phenotypic information | None. |
Breeding history | Backcross: N=10; Intercross: N=10. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Brachydactyly-syndactyly, Zhao type / Orphanet_93409
- Brachydactyly type E / Orphanet_93387
- Synpolydactyly type 1 / Orphanet_295195
- Zygodactyly type 3 / Orphanet_295191
- Syndactyly type 5 / Orphanet_93406
Literature references
- A nested deletion approach to generate Cre deleter mice with progressive Hox profiles.;Hérault Yann, Kmita Marie, Sawaya Chadi C, Duboule Denis, ;2002;The International journal of developmental biology;46;185-91; 11902682
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