STOCK Slamf1tm1Oono Ifnar1tm1Agt/Biat

Status

Available to order

EMMA IDEM:12807
International strain nameSTOCK Slamf1tm1Oono Ifnar1tm1Agt/Biat
Alternative nameIFNAR-/- SLAM KI
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolSlamf1tm1Oono,
Gene/Transgene symbolSlamf1

Information from provider

ProviderRoland Plesker
Provider affiliation Section 4/ZT-Central Animal husbandry, Paul-Ehrlich-Institut
Additional ownerYusuke Yanagi, M.D., Ph.D., Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Genetic informationExon 2 encoding the V domain of mouse Slamf1 (Slam) gene replaced by human SLAM (Ohno S. et al., J Virol., 2007). Murine Ifnar1 gene targeted by germline transmission of disrupted allele (Müller U. et al., Science, 1994).
Phenotypic informationHomozygous:
IFNAR knock-out: abnormal lymphopoiesis, increased susceptibility to viral infection. SLAM knock-in: increased susceptibility of lymphocytic cells to Measles virus.

Heterozygous:
IFNAR knock-out: none SLAM knock-in: increased susceptibility of lymphocytic cells to Measles virus.
Breeding historyBred to homozygosity.
References
  • Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.;Ohno Shinji, Ono Nobuyuki, Seki Fumio, Takeda Makoto, Kura Shinobu, Tsuzuki Teruhisa, Yanagi Yusuke, ;2007;Journal of virology;81;1650-9; 17135325
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedyes

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous B6.129-Slamf1tm1Oono Ifnar1tm1Agt, homozygous B6.129-Slamf1tm1Oono Ifnar1tm1Agt
Breeding at archiving centreSent animals were rederived to the SPF area (barrier) and a colony was built. This colony was used for Speed Cryo IVF and embryo freezing (slow) of double homozygous embryos.
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • increased tumor growth/size / MGI
  • abnormal osteoclast morphology / MGI
  • abnormal response to infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-alpha secretion / MGI
  • decreased interferon-beta secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal inflammatory response / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal immunoglobulin level / MGI
  • abnormal cytokine secretion / MGI
  • corneal vascularization / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI
  • altered susceptibility to infection / MGI
  • immune system phenotype / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • abnormal interferon-gamma secretion / MGI
  • increased circulating interleukin-12 level / MGI

Literature references

  • Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.;Ohno Shinji, Ono Nobuyuki, Seki Fumio, Takeda Makoto, Kura Shinobu, Tsuzuki Teruhisa, Yanagi Yusuke, ;2007;Journal of virology;81;1650-9; 17135325

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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