STOCK Cdh23v-Alb/WtsiH

Status

Available to order

EMMA IDEM:01316
International strain nameSTOCK Cdh23v-Alb/WtsiH
Alternative namev(ALB))
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCdh23v-Alb,
Gene/Transgene symbolCdh23

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Phenotypic informationThis is a hearing impaired, recessive mutant that has a primary defect in the sensory cells of the organ of Corti of the inner ear. Homozygotes exhibit circling behaviour and lack a Preyer reflex. Heterozygotes and wild-types are not distinguishable from each other.
References
  • Localization of the bronx waltzer (bv) deafness gene to mouse chromosome 5.;Bussoli T J, Kelly A, Steel K P, ;1997;Mammalian genome : official journal of the International Mammalian Genome Society;8;714-7; 9321462
  • Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.;Di Palma F, Holme R H, Bryda E C, Belyantseva I A, Pellegrino R, Kachar B, Steel K P, Noben-Trauth K, ;2001;Nature genetics;27;103-7; 11138008

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • bidirectional circling / MGI
  • hyperactivity / MGI
  • decreased litter size / MGI
  • deafness / MGI
  • abnormal ear morphology / MGI
  • abnormal ear physiology / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • abnormal vestibular hair cell stereociliary bundle morphology / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • decreased outer hair cell stereocilia number / MGI
  • absent outer hair cell stereocilia / MGI
  • abnormal inner hair cell stereociliary bundle morphology / MGI
  • head tossing / MGI
  • abnormal outer hair cell kinocilium morphology / MGI
  • vision/eye phenotype / MGI

Literature references

  • Localization of the bronx waltzer (bv) deafness gene to mouse chromosome 5.;Bussoli T J, Kelly A, Steel K P, ;1997;Mammalian genome : official journal of the International Mammalian Genome Society;8;714-7; 9321462
  • Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.;Di Palma F, Holme R H, Bryda E C, Belyantseva I A, Pellegrino R, Kachar B, Steel K P, Noben-Trauth K, ;2001;Nature genetics;27;103-7; 11138008

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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