B6.Cg-Anxa10tm1.1(cre/ERT2)Dstan/Ieg
| Status | Available to order |
| EMMA ID | EM:13609 |
| International strain name | B6.Cg-Anxa10tm1.1(cre/ERT2)Dstan/Ieg |
| Alternative name | Anxa10-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Anxa10tm1.1(cre/ERT2)Dstan, |
| Gene/Transgene symbol | Anxa10 |
Information from provider
| Provider | Daniel Stange |
| Provider affiliation | Universitätsklinikum Carl Gustav Carus Dresden |
| Genetic information | The Anxa10-CreERT2 transgenic mice express a tamoxifen inducible Cre recombinase driven by the annexin A10 (Anxa10) promoter. Mice were generated via homologous recombination by inserting a CreERT2 cassette with a Neomycin resistance cassette flanked by FRT sites after the last exon (12) in the Anxa10 locus. Anxa10 is a stomach specific protein which is expressed in all cells of the stomach epithelium. |
| Phenotypic information | Homozygous:Homozygous Anxa10-CreERT2 mice are phenotypically unaffected.Heterozygous:Heterozygous Anxa10-CreERT2 mice are phenotypically as wild-type mice. |
| Breeding history | The mice were generated with Bruce4 ES cells that have a C57BL/6-Thy1.1 background. The ES cells were transplanted in mice with C57BL/6J background. Offsprings were bred to FlpO mice with C57BL/6J background to remove the neo cassette. From then on mice were crossed as sib-matings for 16 generations (F16). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6J |
Literature references
- Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.;Seidlitz Therese, Chen Yi-Ting, Uhlemann Heike, Schölch Sebastian, Kochall Susan, Merker Sebastian R, Klimova Anna, Hennig Alexander, Schweitzer Christine, Pape Kristin, Baretton Gustavo B, Welsch Thilo, Aust Daniela E, Weitz Jürgen, Koo Bon-Kyoung, Stange Daniel E, ;2019;Gastroenterology;157;1599-1614.e2; 31585123