NOD.B6-Hc1/Cnrm
| Status | Available to order |
| EMMA ID | EM:01390 |
| International strain name | NOD.B6-Hc1/Cnrm |
| Alternative name | NOD.B6-Hc |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Hc1, |
| Gene/Transgene symbol | Hc |
Information from provider
| Provider | Henri-Jean Garchon |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | A 2-base (TA) deletion at positions 62 and 63 of an 83-bases pair exon near the 5-prime end of the hemolytic complement (Hc) gene is found in the non-obese (NOD) but not in C57BL/6 strain, creating a null allele. |
| Phenotypic information | The hemolytic complement is involved in a variety of immune reaction, including the lytic pathway of the complement and the production of anaphylatoxin, notably determining asthma susceptibility. |
| Breeding history | 12 generations of backcrosses. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Deficiency of the fifth component of complement in mice with an inherited complement defect.;Nilsson U R, Müller-Eberhard H J, ;1967;The Journal of experimental medicine;125;1-16; 4959665
- Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951