C57BL/6J-ApcMin/2H

Status

Available to order

EMMA IDEM:01715
International strain nameC57BL/6J-ApcMin/2H
Alternative nameApc, Line II
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolApcMin
Gene/Transgene symbolApc

Information from provider

ProviderMichelle Ellender
Provider affiliationHealth Protection Agency, Chilton, Didcot, Oxon OX11 0RQ
Genetic informationIntestinal polyposis (low multiplicity). The mutation is on chromosome 18 and is a transversion point mutation that alters nucleotide 2549 from a T to an A (mRNA: NM_001360980.1; protein: NM_007462.3). This converts codon 850 from one encoding a leucine to a stop codon (p.Leu850*), truncating the expected polypeptide. The Apc mutation is the homologue of the human APC (adenomatous polyposis coli) gene and the Min (multiple intestinal neoplasia) mice are highly susceptible to spontaneous intestinal tumour formation. This line (#2 or II) is distinct from the other ApcMin line (#5 or V) also submitted to EMMA (strain ID EM:01724). These different ApcMin lines have been described as having different severity of phenotype (Haines J et al., PNAS, 2005, doi: 10.1073/pnas.0500039102).
Phenotypic informationResistance to intestinal tumours.
References
  • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal mammary gland development / MGI
  • abnormal ovarian folliculogenesis / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • abnormal vagina epithelium morphology / MGI
  • decreased body weight / MGI
  • increased incidence of induced tumors / MGI
  • ovary atrophy / MGI
  • uterus atrophy / MGI
  • reproductive system phenotype / MGI
  • adrenal gland hyperplasia / MGI
  • absent nipple / MGI
  • increased mammary gland tumor incidence / MGI
  • mammary gland hyperplasia / MGI
  • anemia / MGI
  • premature death / MGI
  • increased intestinal adenoma incidence / MGI
  • increased intestinal adenocarcinoma incidence / MGI
  • abnormal pregnancy / MGI
  • extended life span / MGI
  • aneuploidy / MGI
  • increased incidence of tumors by chemical induction / MGI
  • decreased intestinal adenoma incidence / MGI
  • decreased hematocrit / MGI
  • hyperlipidemia / MGI
  • melena / MGI
  • rectal prolapse / MGI
  • abnormal intestinal mucosa morphology / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • intestinal obstruction / MGI
  • abnormal intestinal goblet cell morphology / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • intestine polyps / MGI
  • abnormal enterocyte proliferation / MGI
  • decreased T cell number / MGI
  • decreased NK cell number / MGI
  • decreased splenocyte number / MGI
  • neoplasm / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • postnatal growth retardation / MGI
  • increased colonic adenoma incidence / MGI
  • hepatic steatosis / MGI
  • decreased macrophage cell number / MGI
  • increased prostaglandin level / MGI
  • abnormal embryo development / MGI
  • abnormal embryo size / MGI
  • abnormal egg cylinder morphology / MGI
  • abnormal cell physiology / MGI
  • embryonic lethality, complete penetrance / MGI
  • decreased embryo size / MGI
  • embryonic lethality between implantation and placentation / MGI
  • absent mandible / MGI
  • abnormal brain development / MGI
  • acrania / MGI
  • perinatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • absent midbrain / MGI
  • absent forebrain / MGI
MGI phenotypes (gene matching)
  • absent mandible / MGI
  • decreased hematocrit / MGI
  • increased cell proliferation / MGI
  • abnormal digestive system morphology / MGI
  • gastrointestinal hemorrhage / MGI
  • abnormal foregut morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • rectal prolapse / MGI
  • abnormal intestinal mucosa morphology / MGI
  • abnormal mammary gland development / MGI
  • mammary gland hyperplasia / MGI
  • abnormal brain development / MGI
  • abnormal floor plate morphology / MGI
  • abnormal ovarian folliculogenesis / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • abnormal vagina epithelium morphology / MGI
  • dermal cysts / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • increased metastatic potential / MGI
  • abnormal nursing / MGI
  • hunched posture / MGI
  • hyperlipidemia / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • anemia / MGI
  • extended life span / MGI
  • abnormal embryo development / MGI
  • abnormal embryo size / MGI
  • decreased embryo size / MGI
  • incomplete embryo turning / MGI
  • postnatal growth retardation / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • neoplasm / MGI
  • increased pilomatricoma incidence / MGI
  • increased tumor incidence / MGI
  • increased incidence of induced tumors / MGI
  • increased colon adenoma incidence / MGI
  • premature death / MGI
  • abnormal developmental patterning / MGI
  • abnormal embryonic tissue morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • increased intestinal adenoma incidence / MGI
  • hepatic steatosis / MGI
  • increased trichoepithelioma incidence / MGI
  • increased intestinal adenocarcinoma incidence / MGI
  • no phenotypic analysis / MGI
  • abnormal egg cylinder morphology / MGI
  • acrania / MGI
  • colon polyps / MGI
  • intestinal obstruction / MGI
  • melena / MGI
  • rectal hemorrhage / MGI
  • gastric polyps / MGI
  • increased hepatocellular carcinoma incidence / MGI
  • epidermal cyst / MGI
  • decreased tumor growth/size / MGI
  • abnormal tumor morphology / MGI
  • abnormal intestinal goblet cell morphology / MGI
  • increased tumor growth/size / MGI
  • increased osteosarcoma incidence / MGI
  • decreased macrophage cell number / MGI
  • abnormal embryonic epiblast morphology / MGI
  • aneuploidy / MGI
  • abnormal primitive node morphology / MGI
  • cardia bifida / MGI
  • increased incidence of tumors by chemical induction / MGI
  • split notochord / MGI
  • ovary atrophy / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • uterus atrophy / MGI
  • decreased T cell number / MGI
  • increased circulating cholesterol level / MGI
  • cellular phenotype / MGI
  • reproductive system phenotype / MGI
  • abnormal cell physiology / MGI
  • increased apoptosis / MGI
  • abnormal hindbrain development / MGI
  • absent male preputial gland / MGI
  • intestine polyps / MGI
  • increased liver tumor incidence / MGI
  • decreased NK cell number / MGI
  • abnormal anterior visceral endoderm morphology / MGI
  • embryonic lethality / MGI
  • abnormal enterocyte proliferation / MGI
  • adrenal gland hyperplasia / MGI
  • abnormal mesendoderm development / MGI
  • increased small intestine adenocarcinoma incidence / MGI
  • increased large intestine adenocarcinoma incidence / MGI
  • decreased splenocyte number / MGI
  • abnormal pregnancy / MGI
  • absent nipple / MGI
  • increased prostaglandin level / MGI
  • embryonic lethality between implantation and placentation / MGI
  • increased gastrointestinal tumor incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • increased skin tumor incidence / MGI
  • increased stomach tumor incidence / MGI
  • increased osteoma incidence / MGI
  • increased desmoid tumor incidence / MGI
  • gastrointestinal tract polyps / MGI
  • increased adenoma incidence / MGI
  • altered tumor pathology / MGI
  • mortality/aging / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • absent midbrain / MGI
  • embryonic-extraembryonic boundary constriction / MGI
  • absent forebrain / MGI
  • rostral-caudal axis duplication / MGI
  • rostral body truncation / MGI
  • absent neural folds / MGI
  • abnormal head development / MGI
  • decreased intestinal adenoma incidence / MGI
  • abnormal endocardial heart tube morphology / MGI

Literature references

  • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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