B6;129S1-Tnftm1Ljo/Orl

Status

Available to order

EMMA IDEM:00186
International strain nameB6;129S1-Tnftm1Ljo/Orl
Alternative nameTNF-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTnftm1Ljo,
Gene/Transgene symbolTnf

Information from provider

ProviderM Marino
Provider affiliationLudwig Institute for Cancer Research
Phenotypic informationTumor necrosis factor (TNF) plays a critical role in anti-tumor activity and proinflammatory actions. Tnf-/- mice are generated by a targeted mutation of the Tnf gene (insertion of a PGK-neo cassette and acquisition of a novel BamHI site). Tnf-/- mice develop normally and exhibit no consistent histological or morphological abnormalities. Sex ratios, litter size and weight gain of Tnf-/- mice are similar to Tnf+/+ littermates.
References
  • Characterization of tumor necrosis factor-deficient mice.;Marino M W, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old L J, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;8093-8; 9223320

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased susceptibility to bacterial infection / MGI
  • increased susceptibility to fungal infection / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal lung morphology / MGI
  • impaired coordination / MGI
  • abnormal motor coordination/ balance / MGI
  • lung inflammation / MGI
  • decreased apoptosis / MGI
  • abnormal long term spatial reference memory / MGI
  • altered susceptibility to infection / MGI
  • decreased IgG level / MGI
  • abnormal cytokine secretion / MGI
  • decreased susceptibility to autoimmune disorder / MGI
  • abnormal follicular dendritic cell physiology / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased spleen white pulp amount / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • abnormal chemokine secretion / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • liver/biliary system phenotype / MGI
  • increased neutrophil cell number / MGI
  • skin lesions / MGI
  • decreased immunoglobulin level / MGI
  • abnormal neutrophil physiology / MGI
  • skin inflammation / MGI
  • increased susceptibility to parasitic infection / MGI
  • lymph node hypoplasia / MGI
  • increased interferon-gamma secretion / MGI
  • abnormal lymph node cell ratio / MGI
  • increased leukocyte cell number / MGI
  • abnormal Peyer's patch follicle morphology / MGI
  • abnormal Peyer's patch germinal center morphology / MGI
  • abnormal Peyer's patch T cell area morphology / MGI
  • decreased susceptibility to bacterial infection / MGI
  • increased lymphocyte cell number / MGI
  • decreased Peyer's patch number / MGI
  • small Peyer's patches / MGI
  • absent follicular dendritic cells / MGI

Literature references

  • Characterization of tumor necrosis factor-deficient mice.;Marino M W, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old L J, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;8093-8; 9223320

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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