CByIco.129-Cd44tm1Ugu/Ieg
Status | Available to order |
EMMA ID | EM:02018 |
International strain name | CByIco.129-Cd44tm1Ugu/Ieg |
Alternative name | BALB/cByJIco CD44v7-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cd44tm1Ugu, |
Gene/Transgene symbol | Cd44 |
Information from provider
Provider | Ursula Günthert |
Provider affiliation | Institut für Pathologie, University of Basel |
Genetic information | A loxP site was inserted 3' of exon v6 and a neomycin resistance cassette, with a 5' loxP site, was inserted 5' of exon v6 of the Cd44 gene. During insertion, 1.6 kb of sequence was lost in the exon v7 region leading to deficient expression of this variant in homozygous mutant mice (Cd44v7 -/-). |
Phenotypic information | Cd44v7 -/-: Strongly reduced symptoms in autoimmune diseases. |
Breeding history | Backcrossed for 10 generations; kept as homozygous strain on BALB/cByJIco background. |
References |
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Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330
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