129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc]

Status

Available to order

EMMA IDEM:02064
International strain name129.Cg-Tgm2tm1Gml Apoetm1Bres/CljH[cc]
Alternative nameApoE/tTG
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolApoetm1Bres, Tgm2tm1Gml
Gene/Transgene symbolApoe, Tgm2

Information from provider

ProviderChristopher Jackson
Provider affiliationUniversity of Bristol
Genetic informationTargeted null mutation of the apolipoprotein E and tissue transglutaminase genes.
Phenotypic informationNone.
Breeding historyOutcrossed to 129 for more than 10 generations. Currently bred as a closed outbred colony.
References
  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Gene disruption of tissue transglutaminase.;De Laurenzi V, Melino G, ;2001;Molecular and cellular biology;21;148-55; 11113189

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating triglyceride level / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating LDL cholesterol level / IMPC
  • decreased circulating glucose level / IMPC
  • increased circulating bilirubin level / IMPC
  • abnormal tooth morphology / IMPC
  • decreased circulating serum albumin level / IMPC
  • abnormal glucose homeostasis / IMPC
MGI phenotypes (allele matching)
  • abnormal digestive system physiology / MGI
  • increased circulating cholesterol level / MGI
  • abnormal circulating cholesterol level / MGI
  • xanthoma / MGI
  • atherosclerotic lesions / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal neuron morphology / MGI
  • increased circulating VLDL cholesterol level / MGI
  • increased triglyceride level / MGI
  • increased susceptibility to atherosclerosis / MGI
  • decreased circulating HDL cholesterol level / MGI
  • increased circulating triglyceride level / MGI
  • altered response to myocardial infarction / MGI
  • abnormal cardiovascular system physiology / MGI
  • premature death / MGI
  • disorganized myocardium / MGI
  • increased myocardial infarction size / MGI
  • increased tumor growth/size / MGI
  • renal/urinary system phenotype / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • ventricular fibrillation / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • abnormal mitochondrial ATP synthesis coupled electron transport / MGI
  • decreased hematocrit / MGI
  • hyperglycemia / MGI
  • decreased circulating insulin level / MGI
  • decreased erythrocyte cell number / MGI
  • increased insulin sensitivity / MGI
  • impaired glucose tolerance / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal thymus morphology / MGI
  • impaired macrophage phagocytosis / MGI
  • homeostasis/metabolism phenotype / MGI
MGI phenotypes (gene matching)
  • abnormal cochlea morphology / MGI
  • organ of Corti degeneration / MGI
  • abnormal stria vascularis morphology / MGI
  • increased bone mineral density / MGI
  • abnormal circulating cholesterol level / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • increased circulating LDL cholesterol level / MGI
  • decreased circulating LDL cholesterol level / MGI
  • decreased circulating HDL cholesterol level / MGI
  • abnormal triglyceride level / MGI
  • decreased hematocrit / MGI
  • abnormal blood flow velocity / MGI
  • abnormal blood vessel physiology / MGI
  • alopecia / MGI
  • abnormal liver physiology / MGI
  • abnormal adrenal gland morphology / MGI
  • abnormal immune system morphology / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • skin lesions / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • corneal opacity / MGI
  • retinal degeneration / MGI
  • increased anxiety-related response / MGI
  • abnormal nursing / MGI
  • abnormal locomotor behavior / MGI
  • hyperactivity / MGI
  • abnormal response to new environment / MGI
  • decreased exploration in new environment / MGI
  • abnormal spatial learning / MGI
  • increased startle reflex / MGI
  • decreased startle reflex / MGI
  • abnormal kindling response / MGI
  • abnormal skeleton physiology / MGI
  • abnormal lipid level / MGI
  • hyperlipidemia / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating HDL cholesterol level / MGI
  • cardiac hypertrophy / MGI
  • abnormal digestive system physiology / MGI
  • abnormal postnatal growth / MGI
  • hypersecretion of corticosterone / MGI
  • increased circulating corticosterone level / MGI
  • abnormal immune system physiology / MGI
  • lung inflammation / MGI
  • vascular inflammation / MGI
  • abnormal lung volume / MGI
  • deafness / MGI
  • abnormal glucose homeostasis / MGI
  • premature death / MGI
  • abnormal lipid homeostasis / MGI
  • abnormal brain morphology / MGI
  • abnormal gland physiology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal cell-mediated immunity / MGI
  • increased immunoglobulin level / MGI
  • increased IgM level / MGI
  • decreased circulating triglyceride level / MGI
  • abnormal sciatic nerve morphology / MGI
  • abnormal immune serum protein physiology / MGI
  • abnormal thermal nociception / MGI
  • decreased vertical activity / MGI
  • increased thigmotaxis / MGI
  • increased heart weight / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal neuron morphology / MGI
  • no phenotypic analysis / MGI
  • altered response to CNS ischemic injury / MGI
  • abnormal tectorial membrane morphology / MGI
  • impaired muscle relaxation / MGI
  • increased cholesterol efflux / MGI
  • amyloid beta deposits / MGI
  • hypopituitarism / MGI
  • increased cardiac output / MGI
  • nervous system phenotype / MGI
  • oxidative stress / MGI
  • xanthoma / MGI
  • increased autoantibody level / MGI
  • abnormal retinal inner nuclear layer morphology / MGI
  • abnormal bone structure / MGI
  • abnormal myelin sheath morphology / MGI
  • abnormal circulating lipid level / MGI
  • abnormal plasma membrane morphology / MGI
  • increased circulating VLDL triglyceride level / MGI
  • decreased circulating VLDL triglyceride level / MGI
  • increased circulating phospholipid level / MGI
  • arteriosclerosis / MGI
  • increased compact bone thickness / MGI
  • abnormal basilar membrane morphology / MGI
  • cochlear inner hair cell degeneration / MGI
  • cochlear outer hair cell degeneration / MGI
  • abnormal spiral modiolar artery morphology / MGI
  • spiral modiolar artery stenosis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • abnormal synaptic vesicle morphology / MGI
  • abnormal phospholipid level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • decreased systemic vascular resistance / MGI
  • increased spleen weight / MGI
  • abnormal osteoblast physiology / MGI
  • increased B cell number / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • increased circulating VLDL cholesterol level / MGI
  • decreased circulating VLDL cholesterol level / MGI
  • abnormal blood-brain barrier function / MGI
  • increased circulating cholesterol level / MGI
  • decreased circulating cholesterol level / MGI
  • abnormal retinal pigment epithelium morphology / MGI
  • abnormal Bruch membrane morphology / MGI
  • abnormal cholesterol homeostasis / MGI
  • impaired glucose tolerance / MGI
  • increased triglyceride level / MGI
  • abnormal renal glomerulus morphology / MGI
  • atherosclerotic lesions / MGI
  • increased susceptibility to atherosclerosis / MGI
  • altered susceptibility to atherosclerosis / MGI
  • decreased susceptibility to atherosclerosis / MGI
  • liver/biliary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • behavior/neurological phenotype / MGI
  • vascular stenosis / MGI
  • abnormal circulating protein level / MGI
  • increased susceptibility to weight gain / MGI
  • retinal pigment epithelium atrophy / MGI
  • abnormal eye electrophysiology / MGI
  • decreased circulating glucose level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • decreased vasodilation / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • decreased circulating leptin level / MGI
  • decreased cerebral infarction size / MGI
  • abnormal epididymal fat pad morphology / MGI
  • abnormal T cell number / MGI
  • abnormal CD4-positive, alpha beta T cell number / MGI
  • increased CD4-positive, alpha beta T cell number / MGI
  • increased T-helper 2 cell number / MGI
  • abnormal dendrite morphology / MGI
  • decreased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal adrenal cortex morphology / MGI
  • abnormal adrenal medulla morphology / MGI
  • abnormal spatial reference memory / MGI
  • abnormal spatial working memory / MGI
  • thin retinal inner nuclear layer / MGI
  • thin retinal outer nuclear layer / MGI
  • impaired olfaction / MGI
  • increased tumor necrosis factor secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • increased interleukin-6 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • retinal neovascularization / MGI
  • abnormal astrocyte physiology / MGI
  • abnormal fat cell morphology / MGI
  • decreased epididymal fat pad weight / MGI
  • abnormal synapse morphology / MGI
  • increased prostaglandin level / MGI
  • abnormal aorta wall morphology / MGI
  • decreased brain cholesterol level / MGI
  • kidney microaneurysm / MGI
  • increased bone trabecula number / MGI
  • increased lung compliance / MGI
  • increased airway resistance / MGI
  • abnormal lung hysteresivity / MGI
  • abnormal kidney arterial blood vessel morphology / MGI
  • expanded mesangial matrix / MGI
  • mesangiolysis / MGI
  • glomerular capillary thrombosis / MGI
  • dilated glomerular capillary / MGI
  • renal glomerulus lipidosis / MGI
  • increased food intake / MGI
  • increased fluid intake / MGI
  • increased cardiac stroke volume / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • decreased circulating homocysteine level / MGI
  • decreased brown adipose tissue mass / MGI
  • decreased hematocrit / MGI
  • altered response to myocardial infarction / MGI
  • abnormal thymus morphology / MGI
  • increased body weight / MGI
  • abnormal cardiovascular system physiology / MGI
  • hyperglycemia / MGI
  • impaired macrophage phagocytosis / MGI
  • premature death / MGI
  • disorganized myocardium / MGI
  • abnormal T cell physiology / MGI
  • decreased circulating insulin level / MGI
  • decreased erythrocyte cell number / MGI
  • increased insulin sensitivity / MGI
  • no phenotypic analysis / MGI
  • increased myocardial infarction size / MGI
  • abnormal cell adhesion / MGI
  • increased tumor growth/size / MGI
  • decreased susceptibility to injury / MGI
  • impaired glucose tolerance / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • increased macrophage cell number / MGI
  • ventricular fibrillation / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • abnormal mitochondrial ATP synthesis coupled electron transport / MGI

Literature references

  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Gene disruption of tissue transglutaminase.;De Laurenzi V, Melino G, ;2001;Molecular and cellular biology;21;148-55; 11113189

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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