B6.129-Cnr1tm1Zim Cnr2tm1Zim/Ieg

Status

Available to order

EMMA IDEM:02273
International strain nameB6.129-Cnr1tm1Zim Cnr2tm1Zim/Ieg
Alternative nameCnr1 tm1zim/ Cnr2 tm2zim
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCnr2tm1Zim,
Gene/Transgene symbolCnr2

Information from provider

ProviderAndreas Zimmer
Provider affiliationInstitute of Molecular Psychiatry
Genetic informationSee references: PubMed_ID 10318961 and PubMed_ID 10822068.
Phenotypic informationAllergic contact dermatitis.
References
  • Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587
  • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivinghomozygous C57BL/6N

Disease and phenotype information

MGI phenotypes (allele matching)
  • hypoactivity / MGI
  • increased circulating corticosterone level / MGI
  • increased thermal nociceptive threshold / MGI
  • premature death / MGI
  • decreased vertical activity / MGI
  • catalepsy / MGI
  • hypoalgesia / MGI
  • maternal effect / MGI
  • increased follicle stimulating hormone level / MGI
  • increased circulating estradiol level / MGI
  • decreased circulating progesterone level / MGI
  • increased chemical nociceptive threshold / MGI
  • decreased survivor rate / MGI
  • impaired behavioral response to addictive substance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • early parturition / MGI
  • abnormal macrophage physiology / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI

Literature references

  • Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587
  • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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