- hypoactivity / MGI
- increased circulating corticosterone level / MGI
- increased thermal nociceptive threshold / MGI
- premature death / MGI
- decreased vertical activity / MGI
- catalepsy / MGI
- hypoalgesia / MGI
- maternal effect / MGI
- increased follicle stimulating hormone level / MGI
- increased circulating estradiol level / MGI
- decreased circulating progesterone level / MGI
- increased chemical nociceptive threshold / MGI
- decreased survivor rate / MGI
- impaired behavioral response to addictive substance / MGI
- postnatal lethality, incomplete penetrance / MGI
- early parturition / MGI
- abnormal macrophage physiology / MGI
- immune system phenotype / MGI
- reproductive system phenotype / MGI
B6.129-Cnr1tm1Zim Cnr2tm1Zim/Ieg
Status | Available to order |
EMMA ID | EM:02273 |
International strain name | B6.129-Cnr1tm1Zim Cnr2tm1Zim/Ieg |
Alternative name | Cnr1 tm1zim/ Cnr2 tm2zim |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cnr2tm1Zim, |
Gene/Transgene symbol | Cnr2 |
Information from provider
Provider | Andreas Zimmer |
Provider affiliation | Institute of Molecular Psychiatry |
Genetic information | See references: PubMed_ID 10318961 and PubMed_ID 10822068. |
Phenotypic information | Allergic contact dermatitis. |
References |
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Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | homozygous C57BL/6N |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587
- Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211
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