129-Vimtm1Cba/Orl

Status

Available to order

EMMA IDEM:02411
International strain name129-Vimtm1Cba/Orl
Alternative nameVim1/Vim1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolVimtm1Cba,
Gene/Transgene symbolVim

Information from provider

ProviderEmma Colucci-Guyon
Provider affiliationInstitut Pasteur
Genetic informationExon 1 of the vimentin gene is interrupted with a LacZ expression cassette, that is in frame with the first 59 codons of the vimentin gene, followed by a TK-neo resistance cassette. This results in a null mutation of the vimentin locus and in a knock-in of the LacZ gene, which allows following the expression pattern of the vimentin gene via detection of the beta-galactosidase activity. The TKneo cassette is kept in the mutated allele.
Phenotypic informationMice devoid of vimentin develop and reproduce without any obvious defects.
References
  • Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous 129S2/SvPas, homozygous 129S2/SvPas

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal vasoconstriction / MGI
  • abnormal cell morphology / MGI
  • abnormal cerebellum morphology / MGI
  • abnormal cerebellar Purkinje cell layer / MGI
  • Purkinje cell degeneration / MGI
  • abnormal Purkinje cell morphology / MGI
  • decreased Purkinje cell number / MGI
  • increased anxiety-related response / MGI
  • abnormal locomotor behavior / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • impaired balance / MGI
  • abnormal vasodilation / MGI
  • abnormal astrocyte morphology / MGI
  • abnormal motor learning / MGI
  • abnormal cell migration / MGI
  • nervous system phenotype / MGI
  • decreased mean systemic arterial blood pressure / MGI
  • embryo phenotype / MGI
  • cardiovascular system phenotype / MGI
  • respiratory system phenotype / MGI
  • reproductive system phenotype / MGI
  • increased circulating creatinine level / MGI
  • abnormal cell physiology / MGI
  • abnormal Purkinje cell dendrite morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal leukocyte migration / MGI
  • abnormal leukocyte tethering or rolling / MGI
  • abnormal leukocyte adhesion / MGI
  • homeostasis/metabolism phenotype / MGI
  • cellular phenotype / MGI
  • immune system phenotype / MGI
  • abnormal cellular extravasation / MGI

Literature references

  • Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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