STOCK Hnf4atm1(cre)Sdv/H
| Status | Available to order |
| EMMA ID | EM:02506 |
| International strain name | STOCK Hnf4atm1(cre)Sdv/H |
| Alternative name | Hnf4 cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Hnf4atm1(cre)Sdv, |
| Gene/Transgene symbol | Hnf4a |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | Strain carries a knock-in of cre recombinase into the Hnf4a locus. Strain expresses Cre efficiently in the hepatocytes of the developing liver to allow conditional gene deletion or activation in this lineage. |
| Phenotypic information | Homozygous lethal at mid gestation due to defects in liver formation. |
| Breeding history | Backcrossed on a 129S/SvEv background. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- HNF1B-related autosomal dominant tubulointerstitial kidney disease / Orphanet_93111
- MODY / Orphanet_552
- Hyperinsulinism due to HNF4A deficiency / Orphanet_263455
- Atypical Fanconi syndrome-neonatal hyperinsulinism syndrome / Orphanet_544628