- right pulmonary isomerism / MGI
- abnormal autopod morphology / MGI
- abnormal liver morphology / MGI
- abnormal spleen morphology / MGI
- abnormal embryo implantation / MGI
- reduced fertility / MGI
- abnormal cardiovascular system morphology / MGI
- situs inversus / MGI
- abnormal heart atrium morphology / MGI
- left pulmonary isomerism / MGI
- right atrial isomerism / MGI
- abnormal inferior vena cava morphology / MGI
- left atrial isomerism / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal heart atrium auricular region morphology / MGI
- abnormal hepatic portal vein morphology / MGI
- abnormal motile primary cilium morphology / MGI
- heterotaxia / MGI
- absent nodal flow / MGI
STOCK Dnah11iv/H
Status | Available to order |
EMMA ID | EM:02531 |
International strain name | STOCK Dnah11iv/H |
Alternative name | iv |
Strain type | Spontaneous |
Allele/Transgene symbol | Dnah11iv, |
Gene/Transgene symbol | Dnah11 |
Information from provider
Provider | Katharine Hummel |
Provider affiliation | Medical Research Council |
Additional owner | For further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk |
Genetic information | Homozygotes have randomised situs (sidedness). |
Phenotypic information | 50% of homozygotes have situs inversus totalis. |
Breeding history | Complex mixed background; inbred over more than 20 generations. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Primary ciliary dyskinesia / Orphanet_244
MGI phenotypes (allele matching)
Literature references
- Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118
- Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;
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