- absent coat pigmentation / MGI
- diluted coat color / MGI
- abnormal coat/hair pigmentation / MGI
- absent eye pigmentation / MGI
- abnormal coat appearance / MGI
- decreased eye pigmentation / MGI
- mottled coat / MGI
- abnormal eye pigmentation / MGI
- belly spot / MGI
- hypopigmentation / MGI
- variegated eye pigmentation pattern / MGI
- decreased ear pigmentation / MGI
CnbcLmon:NMRI-Tg(tetO-Tyr)1335Lmon Tg(Tyr-rtTA)4111Lmon
Status | Available to order |
EMMA ID | EM:02611 |
International strain name | CnbcLmon:NMRI-Tg(tetO-Tyr)1335Lmon Tg(Tyr-rtTA)4111Lmon |
Alternative name | TRETyBS/HSTyrTET |
Strain type | Spontaneous |
Allele/Transgene symbol | Tyrc, |
Gene/Transgene symbol | Tyr |
Information from provider
Provider | Lluis Montoliu |
Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
Genetic information | Double transgenic mice carrying two constructs for doxycycline-mediated tyrosinase gene regulation (TET-ON model). Animal mouse model of oculocutaneous albinism type 1 (OCA1). It uses the first Tet system developed by H. Bujard and colleagues, therefore the version used of the transactivator was "Tet On/Off" (Tet On scheme, using rtTA) and the version of the Tet promoter was "PTRE". See PubMed ID:15250938. |
Phenotypic information | In the off status, externally undistinguishable from a common albino phenotype. Upon doxycycline/tetracycline treatment from first gestational week pups will show a darker ruby eye colour. Coat colour is not modified by doxycycline/tetracycline treatment. |
Breeding history | Transgenic mice were initially generated in FVB/HanHsd albino inbred mice but expanded in HsdWin:NMRI albino outbred mice to avoid the retinal degeneration mutation (Pdebrd1), carried by the FVB/HanHsd genotype. Mice were bred to double transgenic homozygosity and have been maintained since then as double transgenic homozygous in HsdWin:NMRI albino outbred mice (more than 20 generations). |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | homozygous NMRI, wild-type NMRI |
Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Temperature-sensitive oculocutaneous albinism type 1 / Orphanet_352737
- Oculocutaneous albinism type 1A / Orphanet_79431
- Oculocutaneous albinism type 1B / Orphanet_79434
- Minimal pigment oculocutaneous albinism type 1 / Orphanet_352734
- Ocular albinism with congenital sensorineural deafness / Orphanet_352740
MGI phenotypes (allele matching)
Literature references
- A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.;Giménez Estela, Lavado Alfonso, Giraldo Patricia, Cozar Patricia, Jeffery Glen, Montoliu Lluís, ;2004;Pigment cell research;17;363-70; 15250938
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