C3H.Cg-Fbxo11Jf/H

Status

Available to order

EMMA IDEM:00375
International strain nameC3H.Cg-Fbxo11Jf/H
Alternative nameJeff
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolFbxo11Jf,
Gene/Transgene symbolFbxo11

Information from provider

ProviderRachel Hardisty
Provider affiliationMRC Harwell, Didcot, Oxon, OX11 0RD
Phenotypic informationMice carrying this mutation are small with a short face and are deaf.
References
  • A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.;Hardisty-Hughes Rachel E, Parker Andrew, Brown Steve D M, ;2010;Nature protocols;5;177-90; 20057387
  • A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.;Hardisty-Hughes Rachel E, Tateossian Hilda, Morse Susan A, Romero M Rosario, Middleton Alice, Tymowska-Lalanne Zuzanna, Hunter A Jackie, Cheeseman Michael, Brown Steve D M, ;2006;Human molecular genetics;15;3273-9; 17035249

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

IMPC phenotypes (allele matching)
  • decreased bone mineral density / IMPC
  • decreased body weight / IMPC
  • abnormal retina morphology / IMPC
  • hyperactivity / IMPC
  • abnormal startle reflex / IMPC
  • increased startle reflex / IMPC
  • abnormal vocalization / IMPC
  • abnormal bone mineralization / IMPC
  • thrombocytopenia / IMPC
  • abnormal locomotor activation / IMPC
  • abnormal defecation / IMPC
  • increased lean body mass / IMPC
  • decreased lean body mass / IMPC
  • abnormal behavior / IMPC
  • decreased circulating glucose level / IMPC
  • decreased prepulse inhibition / IMPC
  • increased total body fat amount / IMPC
  • decreased grip strength / IMPC
MGI phenotypes (allele matching)
  • short snout / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • increased susceptibility to otitis media / MGI
  • deafness / MGI
  • abnormal cytokine secretion / MGI
  • abnormal auditory tube / MGI
  • decreased endocochlear potential / MGI
  • abnormal middle ear ossicle morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • absent pinna reflex / MGI
  • abnormal tympanic cavity morphology / MGI
  • middle ear polyps / MGI
  • middle ear effusion / MGI
  • tympanic membrane retraction / MGI
  • excessive cerumen / MGI
  • abnormal pinna reflex / MGI
  • impaired hearing / MGI
  • midline facial cleft / MGI
  • cleft palate / MGI
  • eyelids open at birth / MGI
  • neonatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • short face / MGI

Literature references

  • A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment.;Hardisty-Hughes Rachel E, Parker Andrew, Brown Steve D M, ;2010;Nature protocols;5;177-90; 20057387
  • A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.;Hardisty-Hughes Rachel E, Tateossian Hilda, Morse Susan A, Romero M Rosario, Middleton Alice, Tymowska-Lalanne Zuzanna, Hunter A Jackie, Cheeseman Michael, Brown Steve D M, ;2006;Human molecular genetics;15;3273-9; 17035249

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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