MGI phenotypes (allele matching)
B6.129S2-Gp1bbtm1Frla/Orl
| Status | Available to order |
| EMMA ID | EM:04644 |
| International strain name | B6.129S2-Gp1bbtm1Frla/Orl |
| Alternative name | Gp1bbeta-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gp1bbtm1Frla, |
| Gene/Transgene symbol | Gp1bb |
Information from provider
| Provider | Francois Lanza |
| Provider affiliation | UMR Inserm UdS 949, EFS-Alsace |
| Genetic information | The KO Gp1bbeta -/- was obtained by introducing a Neo cassette into exon 2, eliminating most of the coding sequence. |
| Phenotypic information | Analysis of the hematological parameters of Gp1bbeta-/- revealed the characteristic decreased platelet counts and enlarged platelets of Bernard-Soulier syndrome but normal leukocyte and erythrocyte counts. Flow cytometry analysis showed that in Gp1bbeta -/- mice, Gp1bbeta and Gp1balpha are absent. |
| Breeding history | Backcrossed 15 generations with C57BL/6J mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Bernard-Soulier syndrome / Orphanet_274
- Autosomal dominant macrothrombocytopenia / Orphanet_140957
Literature references
- Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome.;Strassel C, Nonne C, Eckly A, David T, Leon C, Freund M, Cazenave J-P, Gachet C, Lanza F, ;2007;Arteriosclerosis, thrombosis, and vascular biology;27;241-7; 17095718