B6.Cg-Tg(tetO-Creb*)95Brco/Cnbc
| Status | Available to order |
| EMMA ID | EM:04665 |
| International strain name | B6.Cg-Tg(tetO-Creb*)95Brco/Cnbc |
| Alternative name | tetO-ACREB95 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-Creb*)95Brco, |
| Gene/Transgene symbol | Tg(tetO-Creb*)95Brco |
Information from provider
| Provider | Angel Barco |
| Provider affiliation | Servicio de Experimentación Animal, Instituto de Neurociencias de Alicante |
| Genetic information | Tetracycline regulated expression of the CREB inhibitor, A-CREB. Transgene intended to be used in bitransgenic lines after crossing with tTA or rtTA expressing mice. |
| Phenotypic information | After crossing with CamKIIa-tTA the bitransgenic line showed striatal specific expression. Altered neuronal physiology, neurodegeneration, abnormal behavior and altered hippocampal gene expression are described in Cereb Cortex. 2009 Nov;19(11):2535-47. |
| Breeding history | Backcrossed to C57BL/6J for more than 20 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 8-cell |
Literature references
- Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration.;Jancic Dragana, Lopez de Armentia Mikel, Valor Luis M, Olivares Roman, Barco Angel, ;2009;Cerebral cortex (New York, N.Y. : 1991);19;2535-47; 19213815