- rheumatoid arthritis / MGI
- increased circulating tumor necrosis factor level / MGI
- increased tumor necrosis factor secretion / MGI
- increased susceptibility to endotoxin shock / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-2 secretion / MGI
- ileum inflammation / MGI
- increased CD4-positive, alpha-beta memory T cell number / MGI
- arthritis / MGI
- alopecia / MGI
- intestinal inflammation / MGI
- decreased inflammatory response / MGI
- abnormal glucose homeostasis / MGI
- abnormal T cell physiology / MGI
- steatorrhea / MGI
- small intestinal inflammation / MGI
- abnormal T cell subpopulation ratio / MGI
- abnormal food intake / MGI
- decreased susceptibility to diet-induced obesity / MGI
- abnormal circulating leptin level / MGI
- increased dendritic cell number / MGI
- abnormal alpha-beta intraepithelial T cell morphology / MGI
- abnormal intestine physiology / MGI
- abnormal circulating chemokine level / MGI
- abnormal T-helper 17 cell physiology / MGI
- enlarged spleen / MGI
- abnormal myelopoiesis / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal response to transplant / MGI
- increased apoptosis / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased body weight / MGI
- thymus hypoplasia / MGI
- premature death / MGI
B6.129S-Tnftm2Gkl/Flmg
Status | Available to order |
EMMA ID | EM:04974 |
International strain name | B6.129S-Tnftm2Gkl/Flmg |
Alternative name | TNFdeltaARE/+ |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tnftm2Gkl, |
Gene/Transgene symbol | Tnf |
Information from provider
Provider | George Kollias |
Provider affiliation | B.S.R.C. |
Genetic information | A 69 bp deletion encompassing the Tnf AU-rich elements (ARE) was targeted in ES cells together with the neomycin resistance marker (neo) flanked by loxP sequences. Transient expression of cre recombinase in fertilized oocytes from these mice resulted in the excision of the neo gene and the generation of TNFdeltaARE mouse lines. |
Phenotypic information | This strain carries a mutation on the Tnf, lacking the ARE element. It models human pathologies such as chronic inflammatory arthritis (OMIM ID:180300) and Crohn's-like chronic inflammatory bowel disease (OMIM ID:266600). |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
Animals used for archiving | heterozygous C57BL/6, wild-type C57BL/6 |
Stage of embryos | 8-cell |
Disease and phenotype information
MGI allele-associated human disease models
MGI phenotypes (allele matching)
Literature references
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.;Kontoyiannis D, Pasparakis M, Pizarro T T, Cominelli F, Kollias G, ;1999;Immunity;10;387-98; 10204494
- Host and microbiota interactions are critical for development of murine Crohn's-like ileitis.;Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, Seidler U, Becker C, Demengeot J, Furtado G C, Lira S A, Kollias G, ;2016;Mucosal immunology;9;787-97; 26487367
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