C3HeB/FeJ-AlplMhdabap32/Ieg

Status

Available to order

EMMA IDEM:05251
International strain nameC3HeB/FeJ-AlplMhdabap32/Ieg
Alternative nameBAP032
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolAlplMhdabap32
Gene/Transgene symbolAlpl

Information from provider

ProviderSibylle Wagner
Provider affiliationInstitute of Experimental Genetics, GSF Research Centre
Genetic informationMissense mutation at exon 11 of Alpl gene, nucleotide 1217 A to G, resulting in aminoacid substitution Asp 406 Gly.
Phenotypic informationReduced total alkaline phosphatase activity.
Breeding historyC3HeB/FeJ inbred more than 5 generations.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • decreased circulating alkaline phosphatase level / MGI
MGI phenotypes (gene matching)
  • fragile skeleton / MGI
  • decreased bone mineral density / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal tooth development / MGI
  • abnormal long bone metaphysis morphology / MGI
  • decreased leukocyte cell number / MGI
  • abnormal small intestine morphology / MGI
  • abnormal spleen morphology / MGI
  • small spleen / MGI
  • weakness / MGI
  • abnormal spinal nerve morphology / MGI
  • lung hemorrhage / MGI
  • decreased body size / MGI
  • impaired coordination / MGI
  • internal hemorrhage / MGI
  • abnormal digestion / MGI
  • intracranial hemorrhage / MGI
  • apnea / MGI
  • seizures / MGI
  • abnormal tooth morphology / MGI
  • abnormal muscle morphology / MGI
  • abnormal thymus cortex morphology / MGI
  • decreased circulating alkaline phosphatase level / MGI
  • abnormal cementum morphology / MGI
  • abnormal alveolar process morphology / MGI
  • abnormal osteoblast morphology / MGI
  • increased bone resorption / MGI
  • abnormal osteoblast physiology / MGI
  • cachexia / MGI
  • decreased long bone epiphyseal plate size / MGI
  • pale spleen / MGI
  • decreased trabecular bone thickness / MGI
  • abnormal blood homeostasis / MGI
  • decreased total body fat amount / MGI
  • increased bone trabecula number / MGI
  • postnatal lethality, complete penetrance / MGI
  • abnormal tooth root development / MGI
  • decreased alkaline phosphatase activity / MGI
  • abnormal dental pulp morphology / MGI
  • decreased bone mineralization / MGI
  • delayed bone mineralization / MGI
  • thin parietal bone / MGI
  • abnormal dentin mineralization / MGI
  • abnormal cementum mineralization / MGI
  • abnormal odontoblast morphology / MGI
  • abnormal tooth root morphology / MGI
  • short tooth root / MGI
  • abnormal acellular cementum morphology / MGI
  • abnormal cellular cementum morphology / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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