B6.129P2-Cx3cr1^tm1Litt/WeiOrl

Status	Available to order
EMMA ID	EM:00055
International strain name	B6.129P2-Cx3cr1^tm1Litt/WeiOrl
Alternative name	CX3CR1/GFP
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Cx3cr1^tm1Litt,
Gene/Transgene symbol	Cx3cr1

Information from provider

Provider	Steffen Jung
Provider affiliation	The Weizmann Institute of Science
Phenotypic information	Homozygous Cx3cr1/GFP mice have no overt phenotype. Cells expressing Cx3cr1 in heterozygous and homozygous mice are labelled by bright-green fluorescence, incl. microglia, monocytes, dendritic cells and NK cells.
References	Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752 Blood monocytes consist of two principal subsets with distinct migratory properties.;Geissmann Frederic, Jung Steffen, Littman Dan R, ;2003;Immunity;19;71-82; 12871640

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)

paresis / MGI
increased susceptibility to experimental autoimmune encephalomyelitis / MGI
microgliosis / MGI
homeostasis/metabolism phenotype / MGI
paralysis / MGI
demyelination / MGI
brain inflammation / MGI
abnormal leukocyte physiology / MGI
increased neuron apoptosis / MGI
abnormal microglial cell physiology / MGI
abnormal vascular wound healing / MGI
immune system phenotype / MGI
abnormal vascular smooth muscle physiology / MGI
brainstem hemorrhage / MGI
decreased NK cell number / MGI
increased sensitivity to induced morbidity/mortality / MGI
abnormal NK cell physiology / MGI
increased susceptibility to dopaminergic neuron neurotoxicity / MGI
abnormal dendritic cell physiology / MGI
abnormal small intestinal villus morphology / MGI
increased dendritic cell number / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
decreased monocyte cell number / MGI
abnormal retina morphology / MGI
nervous system phenotype / MGI
impaired macrophage chemotaxis / MGI
decreased susceptibility to kidney reperfusion injury / MGI
choroidal neovascularization / MGI

Literature references

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.;Jung S, Aliberti J, Graemmel P, Sunshine M J, Kreutzberg G W, Sher A, Littman D R, ;2000;Molecular and cellular biology;20;4106-14; 10805752
Blood monocytes consist of two principal subsets with distinct migratory properties.;Geissmann Frederic, Jung Steffen, Littman Dan R, ;2003;Immunity;19;71-82; 12871640
Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.;Lantier Louis, Lacroix-Lamandé Sonia, Potiron Laurent, Metton Coralie, Drouet Françoise, Guesdon William, Gnahoui-David Audrey, Le Vern Yves, Deriaud Edith, Fenis Aurore, Rabot Sylvie, Descamps Amandine, Werts Catherine, Laurent Fabrice, ;2013;PLoS pathogens;9;e1003801; 24367259
Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse.;Dénes Adám, Ferenczi Szilamér, Halász József, Környei Zsuzsanna, Kovács Krisztina J, ;2008;Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism;28;1707-21; 18575457
In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue.;Khandoga Alexander Georg, Khandoga Andrej, Reichel Christoph Andreas, Bihari Peter, Rehberg Markus, Krombach Fritz, ;2009;PloS one;4;e4693; 19259262
Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo.;Swinnen Nina, Smolders Sophie, Avila Ariel, Notelaers Kristof, Paesen Rik, Ameloot Marcel, Brône Bert, Legendre Pascal, Rigo Jean-Michel, ;2013;Glia;61;150-63; 23001583
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.;Woodfin Abigail, Voisin Mathieu-Benoit, Beyrau Martina, Colom Bartomeu, Caille Dorothée, Diapouli Frantzeska-Maria, Nash Gerard B, Chavakis Triantafyllos, Albelda Steven M, Rainger G Ed, Meda Paolo, Imhof Beat A, Nourshargh Sussan, ;2011;Nature immunology;12;761-9; 21706006

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6.129P2-Cx3cr1tm1Litt/WeiOrl