C57BL/6NTac-Cap2tm1a(EUCOMM)Wtsi/Ieg

Status

Available to order

EMMA IDEM:05552
International strain nameC57BL/6NTac-Cap2tm1a(EUCOMM)Wtsi/Ieg
Alternative nameEPD0155_4_D08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCap2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolCap2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0155_4_D08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archivingheterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased red blood cell distribution width / IMPC
  • prolonged QT interval / IMPC
  • abnormal locomotor activation / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • cataract / IMPC
  • decreased circulating triglyceride level / IMPC
  • prolonged ST segment / IMPC
  • prolonged RR interval / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
MGI phenotypes (allele matching)
  • decreased survivor rate / MGI
  • decreased body weight / MGI
  • microphthalmia / MGI
  • small pupils / MGI
  • postnatal growth retardation / MGI
  • eye inflammation / MGI
  • premature death / MGI
  • increased susceptibility to infection / MGI
  • dilated heart left ventricle / MGI
  • dilated cardiomyopathy / MGI
  • decreased aerobic running capacity / MGI
  • abnormal impulse conducting system conduction / MGI
  • prolonged QT interval / MGI
  • homeostasis/metabolism phenotype / MGI
  • decreased ventricle muscle contractility / MGI
  • cardiac interstitial fibrosis / MGI
  • congestive heart failure / MGI
  • decreased grip strength / MGI
  • prolonged QRS complex duration / MGI
  • prolonged HV interval / MGI
  • postnatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • enlarged heart / MGI
  • abnormal myocardial fiber morphology / MGI
  • decreased body weight / MGI
  • microphthalmia / MGI
  • small pupils / MGI
  • postnatal growth retardation / MGI
  • eye inflammation / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to infection / MGI
  • dilated heart left ventricle / MGI
  • dilated cardiomyopathy / MGI
  • decreased aerobic running capacity / MGI
  • abnormal impulse conducting system conduction / MGI
  • dilated heart atrium / MGI
  • cardiac fibrosis / MGI
  • prolonged QT interval / MGI
  • dilated heart right atrium / MGI
  • abnormal sarcomere morphology / MGI
  • abnormal M line morphology / MGI
  • abnormal myocardial fiber physiology / MGI
  • decreased myocardial fiber number / MGI
  • abnormal myocardium layer morphology / MGI
  • decreased heart rate / MGI
  • homeostasis/metabolism phenotype / MGI
  • decreased ventricle muscle contractility / MGI
  • cardiac interstitial fibrosis / MGI
  • congestive heart failure / MGI
  • dilated heart ventricle / MGI
  • decreased survivor rate / MGI
  • decreased grip strength / MGI
  • prolonged QRS complex duration / MGI
  • abnormal ventricle myocardium morphology / MGI
  • prolonged HV interval / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • prolonged PQ interval / MGI
  • abnormal I band morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).