- decreased body weight / IMPC
- decreased lean body mass / IMPC
- increased T cell number / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- increased CD8-positive, alpha-beta T cell number / IMPC
- decreased total body fat amount / IMPC
- decreased bone mineral content / IMPC
- decreased effector memory CD4-positive, alpha-beta T cell number / IMPC
- decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
- preweaning lethality, complete penetrance / IMPC
B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:05853 |
International strain name | B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH |
Alternative name | EPD0070_2_G01 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Smc3tm1a(EUCOMM)Wtsi, |
Gene/Transgene symbol | Smc3 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0070_2_G01. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Animals used for archiving | heterozygous C57BL/6Brd-Tyrc-Brd or C57BL/6NTac |
Breeding at archiving centre | Received as frozen sperm. Due to the possible presence of C57BL/6Brd-Tyrc-Brd this strain may produce albino pups if intercrossed. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cornelia de Lange syndrome / Orphanet_199
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased body weight / MGI
- abnormal coat/hair pigmentation / MGI
- decreased lean body mass / MGI
- decreased mean corpuscular hemoglobin / MGI
- decreased total body fat amount / MGI
- decreased bone mineral content / MGI
- abnormal craniofacial morphology / MGI
- increased T cell number / MGI
- postnatal lethality, incomplete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
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