CD1.129-Nogtm1Amc/Orl

Status

Available to order

EMMA IDEM:05988
International strain nameCD1.129-Nogtm1Amc/Orl
Alternative nameNogtm1Amc
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNogtm1Amc
Gene/Transgene symbolNog

Information from provider

ProviderPrzemko Tylzanowski
Provider affiliationDevelopment Growth and Regeneration, University of Leuven
Genetic informationGene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted.
Phenotypic informationThe noggin null embryos have multiple defects including a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.
Breeding historyBackcrossed into CD1 background for more than 20 generations.
References
  • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.;Brunet L J, McMahon J A, McMahon A P, Harland R M, ;1998;Science (New York, N.Y.);280;1455-7; 9603738
  • The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects.;Tylzanowski Przemko, Mebis Liese, Luyten Frank P, ;2006;Developmental dynamics : an official publication of the American Association of Anatomists;235;1599-607; 16598734
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.)

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal placenta morphology / IMPC
  • abnormal embryo turning / IMPC
  • small kidney / IMPC
  • abnormal snout morphology / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal neural tube morphology / IMPC
  • abnormal neural tube closure / IMPC
  • edema / IMPC
  • abnormal vitelline vasculature morphology / IMPC
  • abnormal visceral yolk sac morphology / IMPC
  • abnormal optic vesicle formation / IMPC
  • embryonic growth retardation / IMPC
  • abnormal forebrain development / IMPC
  • abnormal pharyngeal arch morphology / IMPC
  • abnormal blood vessel morphology / IMPC
  • abnormal somite shape / IMPC
  • abnormal heart morphology / IMPC
  • abnormal caudal vertebrae morphology / IMPC
  • abnormal bone structure / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal kidney morphology / IMPC
MGI phenotypes (allele matching)
  • abnormal middle ear morphology / MGI
  • abnormal rib morphology / MGI
  • kinked tail / MGI
  • fused synovial joints / MGI
  • conductive hearing loss / MGI
  • abnormal middle ear ossicle morphology / MGI
  • abnormal stapes morphology / MGI
  • impaired hearing / MGI
  • abnormal styloid process morphology / MGI
  • small thoracic cage / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • kyphosis / MGI
  • abnormal axial skeleton morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • small prostate gland ventral lobe / MGI
  • exencephaly / MGI
  • perinatal lethality / MGI
  • abnormal malleus morphology / MGI
  • fusion of middle ear ossicles / MGI
  • small limb buds / MGI
  • abnormal incus morphology / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal neural tube morphology / MGI
  • abnormal skeleton morphology / MGI
  • perinatal lethality, complete penetrance / MGI
  • short face / MGI
  • abnormal interparietal bone morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • short limbs / MGI
  • incomplete rostral neuropore closure / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal lung morphology / MGI
  • abnormal lung development / MGI
  • abnormal somite development / MGI
  • kinked neural tube / MGI
  • absent tail / MGI
  • abnormal neural tube closure / MGI
  • abnormal vertebral arch morphology / MGI
  • absent vertebral arch / MGI
  • abnormal occipital bone morphology / MGI
  • spina bifida occulta / MGI
  • abnormal neural plate morphology / MGI
  • increased apoptosis / MGI
  • abnormal right lung morphology / MGI
  • abnormal basicranium morphology / MGI
  • edema / MGI
  • abnormal muscle morphology / MGI
  • abnormal limb morphology / MGI
  • vestigial tail / MGI
  • abnormal bone mineralization / MGI
  • abnormal hair follicle development / MGI
  • abnormal muscle fiber morphology / MGI
  • decreased fetal size / MGI
  • abnormal limb bud morphology / MGI
  • hematoma / MGI
  • abnormal cochlea morphology / MGI
  • decreased cochlear coiling / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal eye development / MGI
  • decreased embryo size / MGI
  • abnormal notochord morphology / MGI
  • abnormal ear development / MGI
  • abnormal rostral-caudal patterning of the somites / MGI
  • decreased somite size / MGI
  • abnormal foregut morphology / MGI
  • abnormal esophagus development / MGI
  • esophageal atresia / MGI
  • tracheoesophageal fistula / MGI
  • esophagus stenosis / MGI
  • abnormal head morphology / MGI
  • abnormal diencephalon morphology / MGI
  • abnormal pituitary gland development / MGI
  • absent pituitary gland / MGI
  • abnormal pituitary gland physiology / MGI
  • absent adenohypophysis / MGI
  • absent Rathke's pouch / MGI
  • abnormal Rathke's pouch development / MGI
  • abnormal Rathke's pouch apoptosis / MGI
  • absent pituitary infundibular stalk / MGI
  • abnormal urethra morphology / MGI
  • abnormal male reproductive system morphology / MGI
  • abnormal prostate gland morphology / MGI
  • cryptorchism / MGI
  • absent bulbourethral gland / MGI
  • abnormal septation of the cloaca / MGI
  • anal atresia / MGI
  • abnormal urinary system development / MGI
  • abnormal prostate gland development / MGI
  • abnormal primitive urogenital sinus morphology / MGI
  • pelvic kidney / MGI
MGI phenotypes (gene matching)
  • abnormal malleus morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal middle ear morphology / MGI
  • abnormal interparietal bone morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • abnormal rib morphology / MGI
  • kyphosis / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal head morphology / MGI
  • abnormal foregut morphology / MGI
  • abnormal urethra morphology / MGI
  • short limbs / MGI
  • kinked tail / MGI
  • small prostate gland ventral lobe / MGI
  • abnormal diencephalon morphology / MGI
  • exencephaly / MGI
  • incomplete rostral neuropore closure / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal male reproductive system morphology / MGI
  • abnormal prostate gland morphology / MGI
  • abnormal lung morphology / MGI
  • abnormal lung development / MGI
  • abnormal eye development / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • edema / MGI
  • perinatal lethality / MGI
  • abnormal muscle morphology / MGI
  • abnormal limb morphology / MGI
  • abnormal axial skeleton morphology / MGI
  • abnormal neural tube morphology / MGI
  • cryptorchism / MGI
  • vestigial tail / MGI
  • absent bulbourethral gland / MGI
  • abnormal notochord morphology / MGI
  • abnormal bone mineralization / MGI
  • abnormal septation of the cloaca / MGI
  • anal atresia / MGI
  • decreased cochlear coiling / MGI
  • abnormal esophagus development / MGI
  • fused synovial joints / MGI
  • esophageal atresia / MGI
  • tracheoesophageal fistula / MGI
  • kinked neural tube / MGI
  • absent tail / MGI
  • abnormal hair follicle development / MGI
  • abnormal neural tube closure / MGI
  • fusion of middle ear ossicles / MGI
  • abnormal pituitary gland development / MGI
  • abnormal ear development / MGI
  • abnormal urinary system development / MGI
  • abnormal muscle fiber morphology / MGI
  • decreased fetal size / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • small limb buds / MGI
  • abnormal vertebral arch morphology / MGI
  • absent vertebral arch / MGI
  • conductive hearing loss / MGI
  • abnormal middle ear ossicle morphology / MGI
  • abnormal incus morphology / MGI
  • abnormal stapes morphology / MGI
  • abnormal occipital bone morphology / MGI
  • spina bifida occulta / MGI
  • absent pituitary gland / MGI
  • hearing/vestibular/ear phenotype / MGI
  • abnormal skeleton morphology / MGI
  • abnormal pituitary gland physiology / MGI
  • abnormal limb bud morphology / MGI
  • abnormal neural plate morphology / MGI
  • increased apoptosis / MGI
  • impaired hearing / MGI
  • abnormal styloid process morphology / MGI
  • absent adenohypophysis / MGI
  • abnormal rostral-caudal patterning of the somites / MGI
  • hematoma / MGI
  • abnormal right lung morphology / MGI
  • abnormal prostate gland development / MGI
  • abnormal basicranium morphology / MGI
  • small thoracic cage / MGI
  • abnormal primitive urogenital sinus morphology / MGI
  • esophagus stenosis / MGI
  • perinatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • pelvic kidney / MGI
  • decreased somite size / MGI
  • absent Rathke's pouch / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • abnormal Rathke's pouch development / MGI
  • abnormal Rathke's pouch apoptosis / MGI
  • absent pituitary infundibular stalk / MGI
  • short face / MGI

Literature references

  • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.;Brunet L J, McMahon J A, McMahon A P, Harland R M, ;1998;Science (New York, N.Y.);280;1455-7; 9603738
  • The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects.;Tylzanowski Przemko, Mebis Liese, Luyten Frank P, ;2006;Developmental dynamics : an official publication of the American Association of Anatomists;235;1599-607; 16598734

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