| Status | Available to order |
| EMMA ID | EM:06382 |
| International strain name | B6.129P2-Park7tm1Dsp/Cnbc |
| Alternative name | DJ1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Park7tm1Dsp, |
| Gene/Transgene symbol | Park7 |
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | A targeting construct in which DJ-1 exons 3-5 were replaced with a neomycin (Neo) selectable cassette. The first coding exon of DJ-1 was modified to contain a premature stop codon, resulting in a transcript corresponding to the first eight amino acids of the DJ-1 cDNA. |
| Phenotypic information | DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron numbers in the substantia nigra and fiber densities and dopamine levels in the striatum were normal. However, DJ-1-/- mice showed hypolocomotion when subjected to amphetamine challenge and increased striatal denervation and dopaminergic neuron loss induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). DJ-1-/-embryonic cortical neurons showed increased sensitivity to oxidative, but not nonoxidative, insults. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
