MGI phenotypes (allele matching)
B6.129-Nrxn2tm1Sud/H
| Status | Available to order |
| EMMA ID | EM:06876 |
| International strain name | B6.129-Nrxn2tm1Sud/H |
| Alternative name | Nrxn2tm1Sud |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nrxn2tm1Sud, |
| Gene/Transgene symbol | Nrxn2 |
Information from provider
| Provider | Markus Missler |
| Provider affiliation | Department of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-University Münster |
| Genetic information | A neo cassette replaced the first exon, which contains the complete 5' UTR, start codon, signal peptide and the first LNS (Laminin alpha, Neurexins, and Sex hormone-binding globulin) domain. Immunoblotting of mutant brain confirmed lack of protein. |
| Phenotypic information | Mice homozygous for a knock-out allele show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures. |
| Breeding history | Backcrossed for 8 generations to C57BL/6J. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.;Missler Markus, Zhang Weiqi, Rohlmann Astrid, Kattenstroth Gunnar, Hammer Robert E, Gottmann Kurt, Südhof Thomas C, ;2003;Nature;423;939-48; 12827191