- decreased inflammatory response / MGI
- decreased neuron apoptosis / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal microglial cell physiology / MGI
- decreased susceptibility to kidney reperfusion injury / MGI
- increased renal glomerular filtration rate / MGI
- decreased circulating creatinine level / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased renal tubule apoptosis / MGI
- immune system phenotype / MGI
- enhanced wound healing / MGI
- decreased susceptibility to injury / MGI
- decreased cell proliferation / MGI
- skin hyperplasia / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
NOD.129S2-Parp1tm1Zqw/Ieg
Status | Available to order |
EMMA ID | EM:06909 |
International strain name | NOD.129S2-Parp1tm1Zqw/Ieg |
Alternative name | NOD-Parp1tm1Zqw |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Parp1tm1Zqw, |
Gene/Transgene symbol | Parp1 |
Information from provider
Provider | Volker Burkart |
Provider affiliation | Institute for Clinical Diabetology, German Diabetes Center |
Additional owner | Dr. Z.Q. Wang, Leibniz Institute for Age Research - Fritz Lipmann Institute, Jena, Germany |
Genetic information | A promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice. |
Phenotypic information | Abnormal sensitivity of pancreatic islet cells to beta cell damaging mediators. |
Breeding history | More than 10 backcross generations to female NOD. Every 2nd generation intercrossed, currently inbred. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
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