| Status | Available to order |
| EMMA ID | EM:06915 |
| International strain name | B6.129S2(Cg)-Tbc1d10ctm1.2Psou/Orl |
| Alternative name | Carabin KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tbc1d10ctm1.2Psou, |
| Gene/Transgene symbol | Tbc1d10c |
| Provider | Pauline Soulas-Sprauel |
| Provider affiliation | CRBS (Centre de Recherche en Biomédecine), Inserm UMR 1109 (Immuno-Rhumatologie Moléculaire, IRM) |
| Genetic information | Carabin complete KO mice (see reference Schickel JN et coll, 2012, EMBO Mol Med, PMID: 23109291) |
| Phenotypic information | Increased B cell response in vitro and in vivo. Development of autoantibodies and glomerulonephritis after CpGDNA (TLR9 agonist) injection, in vivo (see reference Schickel JN et coll, 2012, EMBO Mol Med, PMID: 23109291) |
| Breeding history | 12 backcrosses to C57BL/6 mice. Currently backcrossed to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J |
