B6;FVB-Tg(Pcp2-cre)756Mro/H
| Status | Available to order |
| EMMA ID | EM:07326 |
| International strain name | B6;FVB-Tg(Pcp2-cre)756Mro/H |
| Alternative name | L7 Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pcp2-cre)756Mro |
| Gene/Transgene symbol | Tg(Pcp2-cre)756Mro |
Information from provider
| Provider | Sebastian Brandner |
| Provider affiliation | Division of Neuropathology, Institute of Neurology, University College London |
| Genetic information | The transgene carried a cre cDNA fragment cloned into exon 4 of the Pcp2 gene and promoter. Transgenic mice show restricted expression of Cre recombinase in Purkinje cells. |
| Phenotypic information | Transgenic mice show restricted expression of Cre recombinase in Purkinje cells. |
| Breeding history | Outbred onto C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320
- Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella.;Nayeem Naushaba, Kerr Fiona, Naumann Heike, Linehan Jackie, Lovestone Simon, Brandner Sebastian, ;2007;Molecular and cellular neurosciences;34;400-8; 17208451