- altered response to myocardial infarction / MGI
- abnormal leukocyte adhesion / MGI
- abnormal cellular extravasation / MGI
- abnormal stria vascularis morphology / MGI
- increased neutrophil cell number / MGI
- cortical renal glomerulopathies / MGI
- enlarged lymph nodes / MGI
- impaired coordination / MGI
- abnormal spatial learning / MGI
- decreased IgG level / MGI
- conjunctivitis / MGI
- vasculitis / MGI
- salivary gland inflammation / MGI
- premature death / MGI
- abnormal kidney physiology / MGI
- abnormal lymph node morphology / MGI
- increased immunoglobulin level / MGI
- abnormal immunoglobulin level / MGI
- increased IgG level / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- increased urine protein level / MGI
- dilated renal glomerular capsule / MGI
- increased autoantibody level / MGI
- abnormal strial intermediate cell morphology / MGI
- abnormal conjunctival epithelium morphology / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal myocardium layer morphology / MGI
- vision/eye phenotype / MGI
- abnormal enzyme/coenzyme activity / MGI
- CNS inflammation / MGI
- increased plasma cell number / MGI
- podocyte foot process effacement / MGI
- decreased marginal zone B cell number / MGI
- decreased transitional stage B cell number / MGI
- decreased mature B cell number / MGI
- decreased immature B cell number / MGI
- decreased spleen germinal center number / MGI
- renal glomerulus hypertrophy / MGI
- expanded mesangial matrix / MGI
- mesangial cell hyperplasia / MGI
- glomerular crescent / MGI
- increased or absent threshold for auditory brainstem response / MGI
- abnormal thyroid gland morphology / MGI
- enlarged spleen / MGI
- enlarged thymus / MGI
- skin lesions / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal immune system physiology / MGI
- vascular inflammation / MGI
- abnormal gland morphology / MGI
- abnormal thymus medulla morphology / MGI
- abnormal T cell physiology / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- abnormal type III hypersensitivity reaction / MGI
- abnormal immune system organ morphology / MGI
- joint swelling / MGI
- increased circulating serum albumin level / MGI
- thyroid inflammation / MGI
- thymus atrophy / MGI
- abnormal submandibular gland morphology / MGI
- abnormal coronary artery morphology / MGI
- abnormal thyroid follicle morphology / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- abnormal B cell morphology / MGI
- increased thymus weight / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal T cell proliferation / MGI
- increased susceptibility to autoimmune disorder / MGI
- endocrine/exocrine gland phenotype / MGI
- abnormal circulating protein level / MGI
- abnormal T-helper 2 physiology / MGI
- increased circulating total protein level / MGI
- abnormal T cell morphology / MGI
- lymph node hyperplasia / MGI
- enlarged Peyer's patches / MGI
- abnormal marginal zone B cell morphology / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin level / MGI
- abnormal B cell receptor editing / MGI
- abnormal lymph node cell ratio / MGI
- submandibular gland inflammation / MGI
- lacrimal gland inflammation / MGI
- abnormal glomerular capillary morphology / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- increased kidney cell proliferation / MGI
- abnormal glomerular capillary endothelium morphology / MGI
- thymus cortex atrophy / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- demyelination / MGI
- focal hepatic necrosis / MGI
- brain inflammation / MGI
- abnormal kidney morphology / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- increased anti-histone antibody level / MGI
- increased follicular B cell number / MGI
- increased marginal zone B cell number / MGI
- increased transitional stage B cell number / MGI
- increased immature B cell number / MGI
- decreased B cell apoptosis / MGI
- abnormal splenic cell ratio / MGI
- decreased hepatocyte apoptosis / MGI
- increased splenocyte number / MGI
- abnormal NK cell physiology / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- increased renal glomerulus apoptosis / MGI
- increased spleen weight / MGI
- increased blood urea nitrogen level / MGI
- abnormal airway responsiveness / MGI
- decreased eosinophil cell number / MGI
- immune system phenotype / MGI
- increased apoptosis / MGI
- abnormal B cell activation / MGI
- mortality/aging / MGI
- decreased activated T cell number / MGI
- autoimmune response / MGI
- decreased B cell number / MGI
- increased double-negative T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal leukocyte morphology / MGI
- impaired leukocyte tethering or rolling / MGI
- ruffled hair / MGI
- increased body weight / MGI
- increased tumor incidence / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal skin condition / MGI
- epidermal necrosis / MGI
- kidney failure / MGI
- decreased neuron apoptosis / MGI
- decreased apoptosis / MGI
- abnormal vagina weight / MGI
- lacrimal gland atrophy / MGI
- cardiovascular system phenotype / MGI
- abnormal stria vascularis vasculature morphology / MGI
- increased susceptibility to type III hypersensitivity reaction / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased macrophage apoptosis / MGI
- increased IgG3 level / MGI
- kidney inflammation / MGI
- increased gamma-delta T cell number / MGI
- abnormal immune system morphology / MGI
MRL.Cg-Ccr2tm1Blck Faslpr/Cnbc
Status | Available to order |
EMMA ID | EM:08423 |
International strain name | MRL.Cg-Ccr2tm1Blck Faslpr/Cnbc |
Alternative name | 2L-M |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Ccr2tm1Blck, |
Gene/Transgene symbol | Ccr2 |
Information from provider
Provider | Bruno Luckow |
Provider affiliation | Arbeitsgruppe Klinische Biochemie, Klinikum der Universität München, Medizinische Klinik und Poliklinik IV |
Genetic information | Official allele symbols: Ccr2tm1Blck Faslpr. The chemokine receptor Ccr2 has been inactivated by homologous recombination and the resulting Ccr2-deficient mice have been backcrossed to the autoimmune background MRL/lpr, which carries the spontaneous lpr mutation at the Fas locus. |
Phenotypic information | Homozygous:Mice homozygous for the lymphoproliferation spontaneous mutation (Fas |
Breeding history | The Ccr2-deficient mice were originally on a 129 background and the mutant allele has been transferred to the MRL/lpr background by backcrossing. Initially for 7 generations, then after several generations of inbreeding homozygous mice, they have been further backcrossed to N10. Currently they are at N14. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | homozygous 0 |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Autoimmune lymphoproliferative syndrome / Orphanet_3261
MGI phenotypes (allele matching)
Literature references
- Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice.;Pérez de Lema Guillermo, Maier Holger, Franz Tobias J, Escribese Maríia, Chilla Silvia, Segerer Stephan, Camarasa Natalia, Schmid Holger, Banas Bernhard, Kalaydjiev Svetoslav, Busch Dirk H, Pfeffer Klaus, Mampaso Francisco, Schlöndorff Detlef, Luckow Bruno, ;2005;Journal of the American Society of Nephrology : JASN;16;3592-601; 16267157
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