C57BL/6N-Atm1Brd Pth1rtm1a(EUCOMM)Hmgu/WtsiIeg

Status

Available to order

EMMA IDEM:08867
International strain nameC57BL/6N-Atm1Brd Pth1rtm1a(EUCOMM)Hmgu/WtsiIeg
Alternative nameHEPD0733_7_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPth1rtm1a(EUCOMM)Hmgu,
Gene/Transgene symbolPth1r
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0733_7_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased grip strength / IMPC
  • decreased bone mineral content / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (allele matching)
  • abnormal thymus morphology / MGI
  • abnormal lens morphology / MGI
  • hemorrhage / MGI
  • abnormal brain morphology / MGI
  • increased hemangioma incidence / MGI
  • dilated bile duct / MGI
  • enlarged lymphatic vessel / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • herniated liver / MGI
  • decreased total retina thickness / MGI
  • absent segment of posterior cerebral artery / MGI
  • retropharyngeal edema / MGI
  • enlarged paraumbilical vein / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • jugular vein stenosis / MGI
  • blood in lymph vessels / MGI
  • anastomosis between internal carotid artery and basilar artery / MGI
  • abnormal vertebral artery topology / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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