C57BL/6NTac-Atp1a3tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:09026
International strain nameC57BL/6NTac-Atp1a3tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0831_2_H02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAtp1a3tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAtp1a3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0831_2_H02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased anxiety-related response / IMPC
  • hyperactivity / IMPC
  • improved glucose tolerance / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal locomotor behavior / IMPC
  • increased exploration in new environment / IMPC
MGI phenotypes (gene matching)
  • tremors / MGI
  • paralysis / MGI
  • abnormal temporal lobe morphology / MGI
  • abnormal dentate gyrus morphology / MGI
  • convulsive seizures / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • decreased anxiety-related response / MGI
  • ataxia / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • short stride length / MGI
  • decreased exploration in new environment / MGI
  • abnormal spatial learning / MGI
  • abnormal startle reflex / MGI
  • abnormal sleep pattern / MGI
  • limb grasping / MGI
  • increased thermal nociceptive threshold / MGI
  • seizures / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal respiratory function / MGI
  • abnormal sensorimotor gating / MGI
  • increased thigmotaxis / MGI
  • abnormal long term object recognition memory / MGI
  • increased susceptibility to pharmacologically induced seizures / MGI
  • astrocytosis / MGI
  • abnormal response to novel object / MGI
  • nervous system phenotype / MGI
  • enhanced coordination / MGI
  • impaired passive avoidance behavior / MGI
  • abnormal neuron physiology / MGI
  • abnormal behavior / MGI
  • dystonia / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal action potential / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • abnormal spike wave discharge / MGI
  • abnormal xenobiotic pharmacokinetics / MGI
  • microgliosis / MGI
  • decreased prepulse inhibition / MGI
  • abnormal seizure response to inducing agent / MGI
  • environmentally induced seizures / MGI
  • abnormal miniature inhibitory postsynaptic currents / MGI
  • impaired contextual conditioning behavior / MGI
  • enhanced conditioned place preference behavior / MGI
  • enhanced behavioral response to addictive substance / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal hippocampus granule cell morphology / MGI
  • abnormal hippocampus pyramidal cell morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • abnormal habituation / MGI
  • abnormal habituation to a new environment / MGI
  • abnormal sensitization to xenobiotic / MGI
  • decreased frequency of paradoxical sleep / MGI
  • abnormal paradoxical sleep pattern / MGI
  • abnormal non-rapid eye movement sleep pattern / MGI
  • impaired spatial learning / MGI
  • increased kindling response / MGI
  • prolonged circadian behavior period / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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