B6.Cg-Gt(ROSA)26Sortm2(SNAPCaaX)Phep/Cnrm
| Status | Available to order |
| EMMA ID | EM:09058 |
| International strain name | B6.Cg-Gt(ROSA)26Sortm2(SNAPCaaX)Phep/Cnrm |
| Alternative name | Rosa26::SNAPCaaX |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm2(SNAPCaaX)Phep, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Paul Heppenstall |
| Provider affiliation | EMBL Monterotondo |
| Genetic information | This is a cre recombinase-dependent mouse line that expresses a SNAP-tag protein containing a membrane associated CaaX consensus sequence; cre-mediated removal of the stop cassette induces expression of the SNAP-CaaX protein. |
| Phenotypic information | Homozygous:The cre recombinase-dependent conditional expression of SNAPCaax inner membrane protein allows chemical labelling of proteins in specific cell types in vivo.Heterozygous:The cre recombinase-dependent conditional expression of SNAPCaax inner membrane protein allows chemical labelling of proteins in specific cell types in vivo. |
| Breeding history | A9, (C57BL/6 x 129P2/OlaHsd)F1, targeted ES cells. Mutant mice were backcrossed to C57BL/6. They are currently inbreeding. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
| Breeding at archiving centre | The cryopreserved sperm stock was obtained from initially submitted heterozygous mutant males with agouti-like coat color. |
Literature references
- Genetic targeting of chemical indicators in vivo.;Yang Guoying, de Castro Reis Fernanda, Sundukova Mayya, Pimpinella Sofia, Asaro Antonino, Castaldi Laura, Batti Laura, Bilbao Daniel, Reymond Luc, Johnsson Kai, Heppenstall Paul A, ;2015;Nature methods;12;137-9; 25486061