C57BL/6N-Atm1Brd Cxcr2tm1a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:09700
International strain nameC57BL/6N-Atm1Brd Cxcr2tm1a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0664_3_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCxcr2tm1a(EUCOMM)Wtsi,
Gene/Transgene symbolCxcr2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0664_3_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency / Orphanet_420699
IMPC phenotypes (allele matching)
  • increased circulating calcium level / IMPC
  • increased neutrophil cell number / IMPC
  • increased monocyte cell number / IMPC
  • increased granulocyte number / IMPC
  • increased eosinophil cell number / IMPC
  • decreased B cell number / IMPC
  • decreased T cell number / IMPC
  • decreased circulating thyroxine level / IMPC
  • increased circulating creatinine level / IMPC
  • increased circulating total protein level / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • decreased pre-B cell number / IMPC
  • decreased mature B cell number / IMPC
  • decreased immature B cell number / IMPC
  • increased gamma-delta T cell number / IMPC
  • increased circulating magnesium level / IMPC
  • increased effector memory CD4-positive, alpha-beta T cell number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased pre-pro B cell number / IMPC
  • increased Ly6C high monocyte number / IMPC
  • increased Ly6C low monocyte number / IMPC
  • increased KLRG1+ CD8 alpha beta T cell number / IMPC
  • increased memory-marker gamma-delta T cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • increased memory-marker CD4-positive NK T cell number / IMPC
  • increased CD103-positive CD11b-low dendritic cell number / IMPC
  • increased effector memory T-helper cell number / IMPC

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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