- increased circulating calcium level / IMPC
- increased neutrophil cell number / IMPC
- increased monocyte cell number / IMPC
- increased granulocyte number / IMPC
- increased eosinophil cell number / IMPC
- decreased B cell number / IMPC
- decreased T cell number / IMPC
- decreased circulating thyroxine level / IMPC
- increased circulating creatinine level / IMPC
- increased circulating total protein level / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- decreased pre-B cell number / IMPC
- decreased mature B cell number / IMPC
- decreased immature B cell number / IMPC
- increased gamma-delta T cell number / IMPC
- increased circulating magnesium level / IMPC
- increased effector memory CD4-positive, alpha-beta T cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- decreased pre-pro B cell number / IMPC
- increased Ly6C high monocyte number / IMPC
- increased Ly6C low monocyte number / IMPC
- increased KLRG1+ CD8 alpha beta T cell number / IMPC
- increased memory-marker gamma-delta T cell number / IMPC
- increased memory-marker NK cell number / IMPC
- increased memory-marker CD4-positive NK T cell number / IMPC
- increased CD103-positive CD11b-low dendritic cell number / IMPC
- increased effector memory T-helper cell number / IMPC
C57BL/6N-Atm1Brd Cxcr2tm1a(EUCOMM)Wtsi/WtsiOulu
Status | Available to order |
EMMA ID | EM:09700 |
International strain name | C57BL/6N-Atm1Brd Cxcr2tm1a(EUCOMM)Wtsi/WtsiOulu |
Alternative name | EPD0664_3_D02 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Cxcr2tm1a(EUCOMM)Wtsi, |
Gene/Transgene symbol | Cxcr2 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
|
Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0664_3_D02. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | University of Oulu, Oulu, Finland |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency / Orphanet_420699
IMPC phenotypes (allele matching)
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).