B6;129P2-Aicdatm1.1(cre/ERT2)Crey/Ph
| Status | Available to order |
| EMMA ID | EM:09828 |
| International strain name | B6;129P2-Aicdatm1.1(cre/ERT2)Crey/Ph |
| Alternative name | AICDA-Cre-ERT2 |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Aicdatm1.1(cre/ERT2)Crey, |
| Gene/Transgene symbol | Aicda |
Information from provider
| Provider | Claude-Agnes Reynaud |
| Provider affiliation | Faculte de Medecine Paris Descartes - Site Broussais, Unite INSERM 783 "Developpement du systeme immunitaire" |
| Genetic information | Knock-in of a tamoxifen-inducible form of Cre recombinase at the AICDA locus in bacterial artificial chromosome inserted by transgenesis (one copy inserted). |
| Phenotypic information | Homozygous:Not known phenotype.Heterozygous:No phenotype. |
| Breeding history | Transgenesis in the C57BL/6 background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hyper-IgM syndrome type 2 / Orphanet_101089
Literature references
- Multiple layers of B cell memory with different effector functions.;Dogan Ismail, Bertocci Barbara, Vilmont Valérie, Delbos Frédéric, Mégret Jérome, Storck Sébastien, Reynaud Claude-Agnès, Weill Jean-Claude, ;2009;Nature immunology;10;1292-9; 19855380