INFRAFRONTIER-I3 / Mouse Metabolic Phenotyping Training Course

Wednesday, 10 August 2016



INFRAFRONTIER-I3 / Mouse Metabolic Phenotyping Training Course

October 10thOctober 13th at the German Mouse Clinic, Helmholtz Centre Munich


INFRAFRONTIER, the European Research Infrastructure for phenotyping and archiving of model mammalian genomes, offers an excellent training opportunity in mouse metabolic phenotyping. The course will be run by the German Mouse Clinic (GMC) based at the Helmholtz Centre Munich (, and will cover state of the art phenotyping assays used in the energy metabolism, diabetes, clinical chemistry and pathology screens of the GMC. All assays are routinely applied in systemic phenotyping projects of the GMC, and in part also in the phenotyping pipeline of the International Mouse Phenotyping Consortium (IMPC). The course will be run by highly experienced scientists of the GMC, and involve presentations and extensive discussions of assays, experimental design and data analyses.


Course content

Day 1 / October 10th / starting at 12.00

  • German Mouse Clinic phenotyping pipelines, INFRAFRONTIER
  • Glucose metabolism, glucose tolerance test

Clamp technologies


Day 2 / October 11th

  • Metabolic phenotyping
  • Clinical chemistry / liver enzymes
  • Pathology and histological analyses
  • Tour of German Mouse Clinic


Day 3 / October 12th

  • Phenotyping pipeline design
  • Data analysis, statistics
  • Liver spectroscopy, Maldi mass spectrometry
  • Breath gas analysis
  • Metabolomics
  • Tour of Helmholtz Genome Analysis Centre (GAC)


Day 4 / October 13th / ending at 17.00

  • Pigs as animal models for metabolic research
  • Indirect calorimetry
  • Human respirometry


Learning objectives

  • The 4-day course is intending to give participants a comprehensive overview of state of the art technologies and approaches in mouse metabolic phenotyping
  • A strong focus will be on experimental design and phenotyping data analyses


Prospective attendees

  • Course level will be at MS, PhD and Postdoc level. No prior experience with metabolic phenotyping required





The INFRAFRONTIER metabolic phenotyping training course is financially supported

by the EC FP7 funded INFRAFRONTIER-I3 project, project No: 312325