PRIM-TECH3R

Preclinical in vitro Models for the Replacement, Reduction and Refinement of Mouse Models in Preclinical Studies

Photo credit: R. Bengaiev

Project Period:
1 April 2025 – 31 March 2028

Total Cost:
€9M

Grant Agreement:
101188158

Coordinated by
INFRAFRONTIER ERIC

Project Description

The use of mouse models in biomedical research has been pivotal in understanding human diseases due to their genetic and physiological similarities to humans. However, concerns on ethics and translatability have prompted a shift towards alternative methods such as complex in vitro models (CIVMs). PRIM-TECH3R addresses this shift by leveraging advanced technologies to develop reliable mouse and human CIVMs for preclinical studies, aiming to reduce and refine the use of animal models. Through standardised protocols and robust validation procedures, the project will create state-of-the-art in vitro models from mouse disease models, complementing existing in vivo models. This initiative aligns with EU policy objectives and societal demands to address phasing out of animal testing in biomedical research. The project will establish a comprehensive repository of preclinical resources, ensure open access, and foster collaboration between research infrastructures and the biomedical industry. Training programmes will equip personnel with the necessary skills to provide CIVMs to the research community. By achieving these objectives, PRIM-TECH3R aims to advance the state-of-the-art in research infrastructures, facilitate industrial exploitation, and contribute to transformative changes in biomedical research practices.

PRIM-TECH3R’s major outcome

PRIM-TECH3R Consortium

10 European countries
18 institutions
3 Research Infrastructures

Click on the pins to learn more about our project partners!

Work Packages

WP

Title

Lead Partner

WP1

Standardised isolation of relevant mouse cells and pilot mouse biobanking

UKRI

WP2

Development, characterisation, and drug testing studies for Complex in vitro models

CIPHE

WP3

In vivo validation of CIVMs and development of cellular disease models

ICS

WP4

PRIM-TECH3R In Vitro Resource, data management and commercial exploitation

INFRAFRONTIER

WP5

Communication, Dissemination, Training, and Industry Engagement

INFRAFRONTIER

WP6

Project Management and Coordination

INFRAFRONTIER

INFRAPLUS and PRIM-TECH3R will be funded

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PRIM-TECH3R News

Related Media and Resources

PRIM-TECH3R in Euro-BioImaging Virtual Pub

Learn about PRIM-TECH3R in this talk by Michael Raess on 22 Nov 2024

This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101188158.

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