The European Mutant Mouse Archive (EMMA) comprises over 8000 mutant mouse lines that are cryopreserved as frozen sperm and/or embryos. These mutants carry targeted, transgenic, endonuclease-mediated, induced and other types of mutations. A major part of the repository consists of strains donated to EMMA by individual researchers.
In addition, EMMA has built up major collections from large-scale projects which include:
- Lines generated from the International Knockout Mouse Consortium (IKMC) ES cell resources e.g. EUCOMM mice. These are the IKMC strains available from EMMA. For more information about these lines, please have a look at the following documents: allele overview, allele conversion guide and nomenclature for mutant alleles generated in ES cell lines by the IKMC.
- GEMM collection (Genome Editing Mice for Medicine programme): https://www.har.mrc.ac.uk/international-programmes/gemms
- PHENOMIN-ICS Nuclear Receptor collection.
Research tool collections include:
FLP deleter lines
Lines using the TET expression system
Additionally, EMMA has manually curated the nomenclature, description etc. of several archived mouse strains that have been reported to constitute specific disease models. The users can now look for diseases of interest and check if appropriate mouse models, suitable for their research, are available.
All EMMA strains can be searched for and ordered from the list of available EMMA strains.